Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Concept Videos

The Parathyroid Glands00:59

The Parathyroid Glands

The two pairs of parathyroid glands embedded within the posterior surface of the thyroid gland are restricted by a dense capsule around them. These glands comprise two distinct cell populations—parathyroid oxyphil and parathyroid principal cells- pivotal in calcium homeostasis.
Oxyphil cells, whose functions remain elusive, emerge during late puberty, adding a layer of complexity to the parathyroid gland's intricacies. In contrast, principal parathyroid cells undertake a vital role by producing...
Attachment of Sister Chromatids02:57

Attachment of Sister Chromatids

As cells progress into mitosis, the nuclear envelope breaks down, and the condensed chromosomes are exposed to the array of bipolar microtubules of the mitotic spindle. The kinetochore, a large, disc-shaped protein complex, is present at the centromere region of the sister chromatids and acts as a binding site for the microtubules.  Usually, the plus-end of a single microtubule is embedded within the kinetochore. However, some kinetochores first establish lateral contact with the side-wall of a...
Attachment of Sister Chromatids02:57

Attachment of Sister Chromatids

As cells progress into mitosis, the nuclear envelope breaks down, and the condensed chromosomes are exposed to the array of bipolar microtubules of the mitotic spindle. The kinetochore, a large, disc-shaped protein complex, is present at the centromere region of the sister chromatids and acts as a binding site for the microtubules.  Usually, the plus-end of a single microtubule is embedded within the kinetochore. However, some kinetochores first establish lateral contact with the side-wall of a...
Secondary Lymphoid Organs01:15

Secondary Lymphoid Organs

Secondary organs, including lymph nodes, the spleen, and mucosa-associated lymphoid tissue (MALT), work harmoniously to protect us from disease and infection.
The spleen is a vital organ in the lymphatic system, nestled in the upper left side of the abdomen. It is composed of two primary regions: the red pulp and the white pulp, each having distinct functions. The red pulp performs a significant role in blood filtration. It efficiently purges the blood of old or damaged red blood cells and...
The Thyroid Gland01:23

The Thyroid Gland

The thyroid gland is a small, butterfly-shaped gland located in the neck and covers the anterior surface of the trachea. The gland has two lateral lobes connected by a thin tissue mass called the isthmus. Internally, each lobe comprises many small spherical structures known as thyroid follicles, surrounded by a network of blood vessels.
The follicles have a central cavity lined by simple cuboidal to squamous epithelial cells called follicular cells. These cells produce the glycoprotein...
Abnormal Proliferation02:23

Abnormal Proliferation

Under normal conditions, most adult cells remain in a non-proliferative state unless stimulated by internal or external factors to replace lost cells. Abnormal cell proliferation is a condition in which the cell's growth exceeds and is uncoordinated with normal cells. In such situations, cell division persists in the same excessive manner even after cessation of the stimuli, leading to persistent tumors. The tumor arises from the damaged cells that replicate to pass the damage to the daughter...

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

Transient and unique lesion of acantholytic dyskeratosis of the axilla.

JAAD case reports·2025
Same author

Patient Learning Pathway: Identifying Patient Competencies in Teledermatology for Effective Management of Dermatological Conditions.

Journal of cutaneous medicine and surgery·2024
Same author

A case of radiotherapy-induced bullous pemphigoid with unusually delayed onset: A case report.

SAGE open medical case reports·2023
Same author

Improvement in Hailey-Hailey disease with a combination of low-dose naltrexone and oral magnesium chloride: A case report.

SAGE open medical case reports·2021
Same author

A case of dermatomyositis with anti-TIF1γ antibodies revealing isolated para-aortic lymphadenopathy metastatic recurrence of endometrial cancer: A case report.

SAGE open medical case reports·2020
Same author

Trichodysplasia spinulosa in a renal transplant patient: A case report of successful treatment.

SAGE open medical case reports·2020

Related Experiment Video

Updated: May 21, 2026

Use of Electromagnetic Navigational Transthoracic Needle Aspiration (E-TTNA) for Sampling of Lung Nodules
06:03

Use of Electromagnetic Navigational Transthoracic Needle Aspiration (E-TTNA) for Sampling of Lung Nodules

Published on: May 23, 2015

Sister Mary Joseph's nodule.

Sandra Davar1, Dominique Hanna

  • 1Divion of Dermatolgy, CHUM-Hôpital Saint-Luc, Montreal, Quebec.

Journal of Cutaneous Medicine and Surgery
|June 21, 2012
PubMed
Summary
This summary is machine-generated.

Sister Mary Joseph's nodule (SMJN) is a rare umbilical metastasis from intra-abdominal cancers. Recognizing this sign is crucial as it can be the first indicator of an unknown internal malignancy.

More Related Videos

Electromagnetic Navigation Transthoracic Nodule Localization for Minimally Invasive Thoracic Surgery
07:30

Electromagnetic Navigation Transthoracic Nodule Localization for Minimally Invasive Thoracic Surgery

Published on: May 4, 2022

Related Experiment Videos

Last Updated: May 21, 2026

Use of Electromagnetic Navigational Transthoracic Needle Aspiration (E-TTNA) for Sampling of Lung Nodules
06:03

Use of Electromagnetic Navigational Transthoracic Needle Aspiration (E-TTNA) for Sampling of Lung Nodules

Published on: May 23, 2015

Electromagnetic Navigation Transthoracic Nodule Localization for Minimally Invasive Thoracic Surgery
07:30

Electromagnetic Navigation Transthoracic Nodule Localization for Minimally Invasive Thoracic Surgery

Published on: May 4, 2022

Area of Science:

  • Oncology
  • Dermatology
  • Pathology

Background:

  • Sister Mary Joseph's nodule (SMJN) is an uncommon umbilical metastasis from intra-abdominal malignancies.
  • It often presents as the initial clinical manifestation of an occult internal cancer.

Observation:

  • A case report details a 75-year-old man with a history of bladder and prostate cancer who developed an umbilical lesion.
  • Clinical, histopathologic, and radiologic evaluations were conducted to diagnose the umbilical mass.

Findings:

  • Histopathology revealed a urothelial carcinoma, though immunohistochemistry suggested squamous cell carcinoma.
  • Positron emission tomography indicated recurrent bladder cancer, inconsistent with a primary umbilical squamous cell carcinoma.

Implications:

  • SMJN, though rare, is a significant sign of internal malignancy.
  • Early recognition of SMJN is vital for diagnosing underlying cancers, potentially improving patient outcomes.