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Updated: May 21, 2026

Flow-sorting and Exome Sequencing of the Reed-Sternberg Cells of Classical Hodgkin Lymphoma
08:53

Flow-sorting and Exome Sequencing of the Reed-Sternberg Cells of Classical Hodgkin Lymphoma

Published on: June 10, 2017

Long-term survival after treatment for Hodgkin's disease (1973-2002): improved survival with successive 10-year

E M Bessell1, G Bouliotis, S Armstrong

  • 1Department of Clinical Oncology, Nottingham City Hospital, Hucknall Road, Nottingham NG5 1PB, UK. ebessell@hotmail.co.uk

British Journal of Cancer
|June 21, 2012
PubMed

Insights

Survival rates for Hodgkin's lymphoma have significantly improved over three decades due to treatment advances. This study analyzed 745 patients, showing increased 15-year survival from 57% to 83% between 1973 and 2002.

Area of Science:

  • Oncology
  • Epidemiology
  • Biostatistics

Background:

  • The Nottinghamshire Lymphoma Registry tracked lymphoma patients from 1973.
  • A defined population of 1.1 million allowed for cohort analysis of Hodgkin's disease treatment outcomes.
  • Three 10-year cohorts (1973-1982, 1983-1992, 1993-2002) were studied.

Purpose of the Study:

  • To compare survival times across three distinct patient cohorts.
  • To identify prognostic factors influencing Hodgkin's disease outcomes.
  • To estimate relative survival rates over time.

Main Methods:

  • Analysis of survival data for 745 patients diagnosed between 1973 and 2002.
  • Kaplan-Meier method and parametric survival models used for survivorship estimation.
  • Accelerated failure-time regression applied for multivariate analysis.

Main Results:

  • Overall 1-, 5-, and 15-year disease-specific survival rates were 87%, 77%, and 70%, respectively.
  • Significant increase in 15-year survival: 57% (1973-1982) to 83% (1993-2002) (P<0.001).
  • The 20-year actuarial risk of a second malignancy was 12.4% for the earliest cohort and 18.8% for the second.

Conclusions:

  • Treatment advancements have led to significantly longer survival for Hodgkin's disease patients.
  • Effective management of treatment toxicities has contributed to improved patient outcomes.
  • Long-term survival rates demonstrate a positive trend in Hodgkin's disease management over three decades.
Abstract

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