Related Experiment Video
Updated: May 21, 2026

Analysis of Iophenoxic Acid Analogues in Small Indian Mongoose (Herpestes Auropunctatus) Sera for Use as an Oral Rabies Vaccination Biological Marker
Published on: May 31, 2019
Effect of paracetamol on pharmacokinetics of isoniazid in Teddy goats
Humira Nureen1, Zahid Iqbal, Amir Ali Khan
1Department of Physiology and Pharmacology, University of Agriculture, Faisalabad, Pakistan.
Abstract:
In this study the effect of paracetamol on pharmacokinetics (PK) of isoniazid (INH) in Teddy goats was investigated. INH was administered as a single oral dose at 10 mg/kg body weight to every experimental goat. After a wash out period of 7 days, INH and paracetamol (at the rate of 15 mg/kg body weight) were given simultaneously through oral route for investigation of drug interactions. Both times, following drug administration, blood samples were collected at predetermined time intervals from the jugular vein of each animal and analyzed for INH by spectrophotometric analysis. PK parameters were calculated using two compartment open model. When used with paracetamol, the value of biological half life (t1/2β) of INH was significantly decreased (p<0.05) from 2.391 ± 0.216 to 2.17 ± 3.46 hours. The value for apparent volume of distribution (Vd) was also significantly decreased (p<0.05) from 0.905 ± 0.327 to 0.786 ± 0.161 L/kg and total body clearance (CL) was increased insignificantly (p>0.05) from 3.59 ± 2.03 to 4.04 ± 2.61 mL/min/kg. Based on these results, it was concluded that dose of isoniazid should be increased when concomitantly used with paracetamol.
Related Concept Videos
Nonlinear Pharmacokinetics: Dependence of Elimination Half-Life and Dose Clearance
A study on guinea pigs examined the...
Pharmacokinetics in Pediatric Patients: Drug Metabolism
Pharmacogenetics of Phase II Enzymes: N-acetyltransferase, Thiopurine S-methyltransferase, UDP-glucuronosyltransferase
Drug toxicity: Idiosyncratic Reactions
Pharmacokinetics in Geriatric Patients: Effect of Age on Drug Metabolism
Phase I Reactions: Oxidation of Aliphatic and Aromatic Carbon-Containing Systems
Oxidation reactions are fundamental in aromatic carbon-containing systems. An example is the hydroxylation of phenobarbital, a process that transforms it into...
