Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Concept Videos

Multiple Sclerosis l: Introduction01:19

Multiple Sclerosis l: Introduction

Multiple sclerosis is a chronic autoimmune disease of the central nervous system (CNS) that affects the brain, spinal cord, and optic nerves. It is an inflammatory demyelinating disorder and a leading cause of neurological disability in young adults.EpidemiologyMS commonly begins between 20 and 40 years of age and is twice as common in women. Its exact cause remains unclear, but genetic susceptibility contributes, with higher risk in first-degree relatives and identical twins. A greater...
Myasthenia Gravis: Diagnostic Tests01:15

Myasthenia Gravis: Diagnostic Tests

Myasthenia gravis is an autoimmune condition affecting neuromuscular transmission, causing generalized weakness in skeletal muscles. Initial diagnoses rely on patients' signs, symptoms, and medical history. The challenge lies in distinguishing myasthenia from other muscular dystrophies. An important diagnostic feature is the significant improvement of symptoms after administering anticholinesterase inhibitors.
The edrophonium test is a diagnostic tool for myasthenia gravis. It involves...

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

Medial prefrontal cortex and ventrolateral orbitofrontal cortex inputs into the ventrolateral periaqueductal grey region differentially regulate pain and anxiety like behavior.

Neuroscience·2026
Same author

Gating effects of a Cav2.3 calcium channel variant linked to developmental and epileptic encephalopathy.

Neuroscience·2026
Same author

Emerging Pharmacological Strategies for Trigeminal Neuralgia.

CNS drugs·2026
Same author

Molecular Pharmacology of T-Type Calcium Channels and Their Roles in Neurological Disorders.

Medicinal research reviews·2026
Same author

Adjunctive D-cycloserine to intermittent theta-burst transcranial magnetic stimulation in fibromyalgia: a randomized placebo-controlled trial.

Neuropsychopharmacology : official publication of the American College of Neuropsychopharmacology·2026
Same author

Characterization of Three Distinct Loss-of-Function Cav2.3 Variants.

International journal of molecular sciences·2026

Related Experiment Video

Updated: May 21, 2026

The Multiple Sclerosis Performance Test (MSPT): An iPad-Based Disability Assessment Tool
11:35

The Multiple Sclerosis Performance Test (MSPT): An iPad-Based Disability Assessment Tool

Published on: June 30, 2014

Will the real multiple sclerosis please stand up?

Peter K Stys1, Gerald W Zamponi, Jan van Minnen

  • 1Department of Clinical Neurosciences, Hotchkiss Brain Institute, University of Calgary, Calgary, Alberta T2N 4N1, Canada. pstys@ucalgary.ca

Nature Reviews. Neuroscience
|June 21, 2012
PubMed
Summary

Multiple sclerosis (MS) may stem from a primary degenerative condition, with inflammation and autoimmunity representing secondary reactions. This perspective reframes MS understanding, focusing on the

More Related Videos

Magnetic Resonance Imaging of Multiple Sclerosis at 7.0 Tesla
08:51

Magnetic Resonance Imaging of Multiple Sclerosis at 7.0 Tesla

Published on: February 19, 2021

Comprehensive Autopsy Program for Individuals with Multiple Sclerosis
09:41

Comprehensive Autopsy Program for Individuals with Multiple Sclerosis

Published on: July 19, 2019

Related Experiment Videos

Last Updated: May 21, 2026

The Multiple Sclerosis Performance Test (MSPT): An iPad-Based Disability Assessment Tool
11:35

The Multiple Sclerosis Performance Test (MSPT): An iPad-Based Disability Assessment Tool

Published on: June 30, 2014

Magnetic Resonance Imaging of Multiple Sclerosis at 7.0 Tesla
08:51

Magnetic Resonance Imaging of Multiple Sclerosis at 7.0 Tesla

Published on: February 19, 2021

Comprehensive Autopsy Program for Individuals with Multiple Sclerosis
09:41

Comprehensive Autopsy Program for Individuals with Multiple Sclerosis

Published on: July 19, 2019

Area of Science:

  • Neurology
  • Immunology
  • Pathology

Background:

  • Multiple sclerosis (MS) is typically viewed as a central nervous system (CNS) autoimmune and inflammatory disease.
  • The relapsing-remitting course of MS involves inflammatory demyelinating lesions in the CNS.
  • The underlying cause of MS, whether primarily autoimmune/inflammatory or degenerative, remains debated.

Purpose of the Study:

  • To propose a novel conceptualization of multiple sclerosis (MS).
  • To explore the hypothesis that MS is an 'immunological convolution'.
  • To re-evaluate the role of inflammation and autoimmunity in MS pathogenesis.

Main Methods:

  • Conceptual analysis and theoretical argumentation.
  • Review of existing literature on MS pathology and immunology.
  • Comparative analysis of inflammatory and non-inflammatory MS forms.

Main Results:

  • The study posits that MS may arise from a primary degenerative disorder.
  • Inflammation and autoimmunity in MS are proposed as secondary reactions to this primary condition.
  • Non-inflammatory primary progressive MS is suggested as the 'true' form of the disease.

Conclusions:

  • MS may be better understood as a complex interplay between degeneration and aberrant immune responses.
  • Rethinking MS etiology could lead to new diagnostic and therapeutic strategies.
  • Focusing on primary degenerative aspects may offer deeper insights into MS pathophysiology.