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Updated: May 21, 2026

Proton Transfer and Protein Conformation Dynamics in Photosensitive Proteins by Time-resolved Step-scan Fourier-transform Infrared Spectroscopy
Published on: June 27, 2014
High sensitivity transient infrared spectroscopy: a UV/Visible transient grating spectrometer with a heterodyne
Paul M Donaldson1, Halina Strzalka, Peter Hamm
1Institute of Physical Chemistry, University of Zürich, Winterthurerstrasse 190, Zürich CH-8057, Switzerland.
Abstract:
We describe here a high sensitivity means of performing time resolved UV/Visible pump, infrared probe spectroscopy using optically Heterodyne Detected UV-IR Transient Gratings. The experiment design employed is simple, robust and includes a novel means of generating phase locked pulse pairs that relies on only mirrors and a beamsplitter. A signal to noise ratio increase of 24 compared with a conventional pump-probe arrangement is demonstrated.
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