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[Therapeutic strategies to prevent chronic kidney disease progression]
1Abteilung für Nieren- und Hochdruckerkrankungen, Medizinische Hochschule Hannover, Carl-Neuberg-Str. 1, 30625, Hannover, Deutschland. schmidt.bernhard@mh-hannover.de
Insights
Chronic kidney disease (CKD) management requires individualized treatment. Lowering blood pressure and proteinuria are key, but aggressive targets are questioned, necessitating personalized care considering patient risk factors.
Area of Science:
- Nephrology
- Cardiology
- Internal Medicine
Context:
- Chronic kidney disease (CKD) is a widespread health issue.
- Effective CKD progression management strategies are crucial.
- Current aggressive blood pressure goals are under scrutiny due to potential risks.
Purpose:
- To review key measures for slowing CKD progression.
- To discuss the importance of individualized patient treatment.
- To highlight modifiable risk factors beyond blood pressure.
Summary:
- Lowering blood pressure and proteinuria are primary interventions for CKD.
- Individualized treatment plans are essential, considering cardiovascular damage and progression risk.
- Other critical modifiable factors include blood glucose, lipids, anemia, uric acid, vitamin D, protein intake, and smoking.
Impact:
- Promotes personalized medicine in CKD care.
- Encourages a balanced approach to blood pressure management.
- Provides a comprehensive overview of multifactorial CKD risk reduction.
Abstract:
Chronic kidney disease (CKD) is highly prevalent. Independent from the underlying disease, measures capable of decreasing the progression of CKD have been identified. Lowering of blood pressure and proteinuria are most important. As the potential risk of aggressive blood pressure-lowering strategies has become obvious, the current very low blood pressure goals are doubted. Thus, patients have to be treated individually taking into consideration each patient's preexisting cardiovascular damage and the risk of CKD progression. Additional modifiable risk factors are blood glucose in diabetic patients, lipids, anemia, uric acid, vitamin D, protein intake, and smoking.
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