Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Concept Videos

Papillary Dermis01:11

Papillary Dermis

Dermis
The dermis might be considered the "core" of the integumentary system, as distinct from the epidermis and hypodermis. It contains blood and lymph vessels, nerves, and other structures, such as hair follicles and sweat glands. The dermis is made of two layers of connective tissue that comprise an interconnected mesh of elastin and collagenous fibers, produced by fibroblasts.
Papillary Layer
The papillary layer is made of loose, areolar connective tissue, which means the collagen and...
Reticular Dermis01:15

Reticular Dermis

The papillary and reticular dermis are the two layers of the dermis. They are made of connective tissue with fibers of collagen extending from one to the other, making the border between the two somewhat indistinct. The dermal papillae extending into the epidermis belong to the papillary layer, whereas the dense collagen fiber bundles below belong to the reticular layer.
Reticular Layer
Underlying the papillary layer is the much thicker reticular layer, composed of dense, irregular connective...
The Retinoblastoma Gene01:20

The Retinoblastoma Gene

Tumor suppressor genes are normal genes that can slow down cell division, repair DNA mistakes, or program the cells for apoptosis in case of irreparable damage. Hence, they play an essential role in preventing the proliferation of damaged cells.
The first-ever tumor suppressor gene called Rb was identified in retinoblastoma - a rare eye tumor in children. In inherited forms of the disease, a child inherits one defective copy of the Rb gene, which predisposes them to retinoblastoma. However,...
Skin Cancer01:30

Skin Cancer

Skin cancer is a type of cancer that occurs when there is an abnormal growth of skin cells, usually triggered by damage to the DNA within the skin cells. It is primarily caused by exposure to ultraviolet (UV) radiation from the sun or artificial sources like tanning beds. Skin cancer is the most common type of cancer worldwide, and its incidence continues to rise.
Basal Cell Carcinoma (BCC): BCC is the most common type of skin cancer, accounting for about 80% of cases. It typically develops in...
Multipotency and Niche of Bulge Stem Cell01:06

Multipotency and Niche of Bulge Stem Cell

A hair follicle or HF is a small part of the skin that produces the hair shaft. Paul Gerson Unna was the first to observe a bulge in the human hair follicle's outer root sheath (ORS). The bulge is present between the sebaceous gland and the arrector pili muscle and is the niche for hair follicle stem cells (HFSCs). The bulge is also a niche for melanocyte stem cells, and their loss results in graying of hair. The HFSCs express Sox9 and Lhx2, which help them maintain stemness and prevent...
Accessory Structures of the Skin: Hair Growth and Types01:20

Accessory Structures of the Skin: Hair Growth and Types

Hair growth begins with the production of keratinocytes by the basal cells of the hair bulb. As new cells are deposited at the hair bulb, the hair shaft is pushed through the follicle toward the surface. Keratinization is completed as the cells are pushed to the skin surface to form the shaft of hair that is externally visible. The external hair is completely dead and composed entirely of keratin. Hair can be cut or shaven without damaging the hair structure because the cut is superficial. Most...

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

Use of fractional and microablative CO2 laser in cases of vulvar lichen sclerosus: a clinical-histological analysis.

Lasers in medical science·2026
Same author

EZH2 in Acral Lentiginous Melanoma: Molecular, Epigenetic, and Therapeutic Perspectives.

Oncology research·2026
Same author

Incidence and mortality of cutaneous melanoma stratified by sex, age, and age group - An analysis of the Brazilian population from 2013 to 2023.

Anais brasileiros de dermatologia·2026
Same author

Histopathological evaluation of facial melasma treated with oral tranexamic acid alone and in combination with ketotifen.

Anais brasileiros de dermatologia·2026
Same author

Pigmented epithelioid melanocytoma: two cases with dermoscopic findings.

Anais brasileiros de dermatologia·2026
Same author

Dermoscopic rainbow pattern in malignant blue nevus.

Anais brasileiros de dermatologia·2026

Related Experiment Video

Updated: May 21, 2026

Anterior High-Resolution Optical Coherence Tomography in the Diagnosis and Therapeutic Monitoring of Ocular Surface Squamous Neoplasia
06:15

Anterior High-Resolution Optical Coherence Tomography in the Diagnosis and Therapeutic Monitoring of Ocular Surface Squamous Neoplasia

Published on: August 9, 2024

Spitz nevus and Reed nevus.

Alessandra Yoradjian1, Mílvia Maria Simões e Silva Enokihara, Francisco Macedo Paschoal

  • 1ABC School of Medicine, Santo André, SP, Brazil. alessandraderma@hotmail.com

Anais Brasileiros De Dermatologia
|June 21, 2012
PubMed
Summary

Spitz and Reed nevi are unique melanocytic lesions that can be mistaken for melanoma. Dermoscopy aids in diagnosis, but challenging cases require further research for accurate treatment and patient management.

Area of Science:

  • Dermatology
  • Dermatopathology
  • Oncology

Background:

  • Spitz and Reed nevi, also known as spindle or epithelioid cell nevi, represent a distinct category of melanocytic lesions.
  • Their classification and nomenclature remain subjects of ongoing debate within the medical community.
  • Accurate differentiation from melanoma is crucial to prevent misdiagnosis and inappropriate treatment.

Purpose of the Study:

  • To explore the key characteristics of Spitz and Reed nevi.
  • To emphasize the role of dermoscopy in diagnosing these lesions.
  • To enhance understanding of their natural history, treatment, and follow-up protocols.

Main Methods:

  • Review of clinical, dermoscopic, and histopathological features of Spitz and Reed nevi.
  • Emphasis on dermoscopic findings for diagnostic accuracy.

More Related Videos

Investigating Retinal Circuits and Molecular Localization by Pre-Embedding Immunoelectron Microscopy
05:15

Investigating Retinal Circuits and Molecular Localization by Pre-Embedding Immunoelectron Microscopy

Published on: July 12, 2024

Identifying, Diagnosing, and Grading Malignant Peripheral Nerve Sheath Tumors in Genetically Engineered Mouse Models
08:57

Identifying, Diagnosing, and Grading Malignant Peripheral Nerve Sheath Tumors in Genetically Engineered Mouse Models

Published on: May 17, 2024

Related Experiment Videos

Last Updated: May 21, 2026

Anterior High-Resolution Optical Coherence Tomography in the Diagnosis and Therapeutic Monitoring of Ocular Surface Squamous Neoplasia
06:15

Anterior High-Resolution Optical Coherence Tomography in the Diagnosis and Therapeutic Monitoring of Ocular Surface Squamous Neoplasia

Published on: August 9, 2024

Investigating Retinal Circuits and Molecular Localization by Pre-Embedding Immunoelectron Microscopy
05:15

Investigating Retinal Circuits and Molecular Localization by Pre-Embedding Immunoelectron Microscopy

Published on: July 12, 2024

Identifying, Diagnosing, and Grading Malignant Peripheral Nerve Sheath Tumors in Genetically Engineered Mouse Models
08:57

Identifying, Diagnosing, and Grading Malignant Peripheral Nerve Sheath Tumors in Genetically Engineered Mouse Models

Published on: May 17, 2024

  • Discussion of current research, including molecular studies for challenging cases.

    • Main Results:

    • Dermoscopy demonstrates significant accuracy (up to 93%) in diagnosing melanocytic lesions.
    • Spitz and Reed nevi present unique diagnostic challenges, particularly "borderline" lesions.
    • Further research, including molecular analysis, is needed for complex cases.

    Conclusions:

    • Accurate diagnosis of Spitz and Reed nevi is essential for appropriate patient management.
    • Dermoscopy is a valuable tool, but challenging lesions require continued investigation.
    • Understanding the natural history and optimizing treatment/follow-up are critical for these nevi.