Related Experiment Video
Updated: May 21, 2026
06:38
In Vitro Modeling of Down Syndrome Neurogenesis Using Human-Induced Pluripotent Stem Cells
Published on: March 7, 2025
Generalized Lichen nitidus associated with Down's syndrome: case report
Luciane Francisca Fernandes Botelho1, João Paulo Junqueira de Magalhães, Marília Marufuji Ogawa
1Federal University of São Paulo, Brazil. lucianebotelho@hotmail.com
Anais Brasileiros De Dermatologia
|June 21, 2012
Summary
Lichen nitidus, a skin condition causing small papules, is rarely associated with Down syndrome. This report details the fourth known case linking these two conditions.
Area of Science:
- Dermatology
- Genetics
Background:
- Lichen nitidus is a rare skin condition of unknown cause, presenting as small, flesh-colored papules.
- It typically affects the genitalia, limbs, trunk, and abdomen, and is usually asymptomatic or causes mild itching.
- Generalized lichen nitidus is uncommon.
Observation:
- This case report describes a patient with lichen nitidus.
- The patient also has Down Syndrome.
- This represents the fourth documented instance of this association.
Findings:
- The study highlights a rare co-occurrence of lichen nitidus and Down Syndrome.
- The clinical presentation of lichen nitidus in this case aligns with typical descriptions.
- The association, though rare, warrants further investigation.
Implications:
- This case contributes to the limited literature on lichen nitidus and Down Syndrome.
- Understanding this association may aid in early diagnosis and management of both conditions.
- Further research is needed to explore potential pathogenetic links.
Related Concept Videos
01:29Alzheimer Disease l: Introduction
Alzheimer disease is a chronic, progressive, and irreversible neurodegenerative disorder and the most common cause of dementia in older adults. It leads to gradual neuronal loss, causing cognitive decline, behavioral changes, and loss of functional independence.Risk Factors and EtiologyThe disease is multifactorial. Age is the strongest risk factor, with prevalence doubling every 5 years after age 65. Genetic factors include mutations in genes such as APP, PSEN1, and PSEN2, which are associated...
01:21Huntington Disease l: Introduction
Huntington disease or HD is a progressive, fatal neurodegenerative disorder inherited in an autosomal dominant pattern.PathophysiologyIt is caused by expansion of the CAG trinucleotide repeat in the HTT gene on chromosome 4 (4p16.3), producing an abnormal huntingtin protein with an expanded polyglutamine tract. This misfolded protein disrupts cellular function, leading to neuronal death. Normal alleles have ≤26 repeats, 27–35 are intermediate (risk of expansion), 36–39 show reduced penetrance,...
01:49Meiosis I
Meiosis is a carefully orchestrated set of cell divisions, the goal of which—in humans—is to produce haploid sperm or eggs, each containing half the number of chromosomes present in somatic cells elsewhere in the body. Meiosis I is the first such division, and involves several key steps, among them: condensation of replicated chromosomes in diploid cells; the pairing of homologous chromosomes and their exchange of information; and finally, the separation of homologous chromosomes by a...
01:17Karyotyping
Overview
01:29Intellectual Disability
Intellectual disability (ID) is a neurodevelopmental condition characterized by deficits in intellectual and adaptive functioning that manifest during the developmental period. This condition encompasses challenges in reasoning, memory, problem-solving, and learning, accompanied by impairments in everyday life skills, such as communication, self-care, and social interactions. Intellectual disability affects approximately 1% of the population in the United States, impacting an estimated 5...
01:33Pleiotropy
Pleiotropy is the phenomenon in which a single gene impacts multiple, seemingly unrelated phenotypic traits. For example, defects in the SOX10 gene cause Waardenburg Syndrome Type 4, or WS4, which can cause defects in pigmentation, hearing impairments, and an absence of intestinal contractions necessary for elimination. This diversity of phenotypes results from the expression pattern of SOX10 in early embryonic and fetal development. SOX10 is found in neural crest cells that form melanocytes,...