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Updated: May 21, 2026

Modeling Paracrine Noncanonical Wnt Signaling In Vitro
Published on: December 10, 2021
Cartilage development and degeneration: a Wnt Wnt situation
Katherine Ann Staines1, Vicky Elizabeth Macrae, Colin Farquharson
1The Roslin Institute and Royal-Dick School of Veterinary Studies, The University of Edinburgh, Easter Bush, Midlothian, Scotland. katherine.staines@roslin.ed.ac.uk
Abstract:
The Wnt signaling pathway plays a crucial role in the development and homeostasis of a variety of adult tissues and, as such, is emerging as an important therapeutic target for numerous diseases. Factors involved in the Wnt pathway are expressed throughout limb development and chondrogenesis and have been shown to be critical in joint homeostasis and endochondral ossification. Therefore, in this review, we discuss Wnt regulation of chondrogenic differentiation, hypertrophy and cartilage function. Moreover, we detail the role of the Wnt signaling pathway in cartilage degeneration and its potential to act as a target for therapy in osteoarthritis.
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