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Urinary plasminogen activator activity in progressive renal failure.
The Korean Journal of Internal Medicine
|January 1, 1990
Summary
This study reveals that urine plasminogen activator (U-PA) activity in remnant nephrons correlates with urine concentration and is linked to fractional sodium excretion as kidney function declines. These findings suggest U-PA
Area of Science:
- Nephrology
- Biochemistry
- Urology
Background:
- Plasminogen activator is crucial for kidney function.
- Understanding its production in failing kidneys is vital.
Purpose of the Study:
- To investigate urine plasminogen activator (U-PA) production by functional nephrons during renal function decline.
- To evaluate U-PA activity in remnant nephrons of patients with varying degrees of renal failure.
Main Methods:
- Measured U-PA activity using the fibrin plate method in 73 patients with renal dysfunction and 1 healthy individual.
- Analyzed urine osmolality, creatinine, fractional sodium excretion (FeNa), and glomerular filtration rate (GFR).
Main Results:
- U-PA activity correlated with urine osmolality and creatinine, indicating distal nephron concentration.
- A pattern similar to FeNa increase was observed between total U-PA activity/GFR and GFR.
- A significant direct correlation was found between total U-PA activity/GFR and FeNa (r = 0.775, P < 0.0001).
Conclusions:
- Remnant nephrons concentrate urine plasminogen activator.
- U-PA activity normalized to GFR is a potential indicator of tubular function in chronic kidney disease.
- Further research is needed to elucidate the precise role of U-PA in renal failure progression.