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Establishment and Characterization of Patient-Derived Xenograft Models of Anaplastic Thyroid Carcinoma and Head and Neck Squamous Cell Carcinoma
Published on: June 2, 2023
Hurthle cell carcinoma of the thyroid
Mark Anthony S Sandoval1, Elizabeth Paz-Pacheco
1Section of Endocrinology, Diabetes and Metabolism, Department of Medicine, Philippine General Hospital, University of the Philippines, Manila, Philippines. markanthony_sandoval@yahoo.com
A patient with a thyroid nodule was diagnosed with Hurthle cell carcinoma. Treatment included surgery, radioactive iodine, and levothyroxine, resulting in no evidence of disease.
Area of Science:
- Endocrinology
- Oncology
- Surgical Pathology
Background:
- A 63-year-old male presented with a 2-year history of a non-toxic thyroid nodule.
- Initial fine needle aspiration suggested papillary thyroid carcinoma.
Observation:
- Microscopic examination post-total thyroidectomy confirmed Hurthle cell carcinoma.
- The patient received radioactive iodine therapy and levothyroxine treatment.
Findings:
- Post-therapy iodine-131 scan showed limited thyroid tissue remnants in the anterior neck.
- Four months post-treatment, thyroglobulin levels were low with no evidence of disease.
Implications:
- This case highlights the diagnostic and therapeutic pathway for Hurthle cell carcinoma.
- Successful management led to a favorable outcome with no recurrence observed.
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