Related Experiment Video
Updated: May 21, 2026

A 3D Organotypic Melanoma Spheroid Skin Model
Published on: May 18, 2018
Dyskeratosis congenita with malignant transformation
Jay Gopal Ray1, Niharika Swain, Ranjan Ghosh
1Department of Oral and Maxillofacial Pathology, Dr R Ahmed Dental College & Hospital, Kolkata, India. jaygopalray@yahoo.co.in
Dyskeratosis congenita (DC) is a rare disorder. This case highlights rapid malignant transformation in a sporadic DC patient, emphasizing the need for vigilance in unusual presentations.
Area of Science:
- Dermatology
- Oncology
- Genetics
Background:
- Dyskeratosis congenita (DC) is a rare genodermatosis.
- Characterized by a triad: dystrophic nails, reticular skin pigmentation, and leukoplakic patches.
- Leukoplakic patches carry a high risk of malignant transformation.
Observation:
- Presents a sporadic case of DC.
- No similar clinical presentation in first or second-degree relatives.
- Observed rapid malignant transformation in a non-homogeneous nodulo-speckled leukoplakic patch on the tongue dorsum.
Findings:
- The sporadic DC case lacked familial history.
- Rapid malignant transformation occurred in a specific leukoplakic lesion.
- The lesion's morphology was non-homogeneous and nodulo-speckled.
Implications:
- Highlights the potential for de novo or sporadic DC.
- Underscores the aggressive nature of malignant transformation in DC.
- Suggests careful monitoring of diverse leukoplakic lesions in DC patients is crucial.
More Related Videos
09:37Combining Reflectance Confocal Microscopy with Optical Coherence Tomography for Noninvasive Diagnosis of Skin Cancers via Image Acquisition
Published on: August 18, 2022
04:12Chemical-Induced Skin Carcinogenesis Model Using Dimethylbenz[a]Anthracene and 12-O-Tetradecanoyl Phorbol-13-Acetate (DMBA-TPA)
Published on: December 19, 2019
Related Concept Videos
Skin Cancer
Basal Cell Carcinoma (BCC): BCC is the most common type of skin cancer, accounting for about 80% of cases. It typically develops in...
Cellular Adaptation IV: Dysplasia and Metaplasia
Abnormal Proliferation
Abnormal Proliferation
Skin Diseases and Disorders
Gram-positive Staphylococcus spp. and Streptococcus spp. are responsible for many of the most common skin infections. However, many...
Desmosomes