Related Experiment Video
Updated: May 21, 2026

Detection of Small GTPase Prenylation and GTP Binding Using Membrane Fractionation and GTPase-linked Immunosorbent Assay
Published on: November 11, 2018
Rhabdomyolysis with simvastatin
Brijesh R Patel1, Maitrayee Choudhury
1Colchester General Hospital, Colchester, UK. brijeshrpatel@doctors.org.uk
Abstract:
As 3-hydroxy-3-methylglutaryl coenzyme A (HMG-CoA) reductase inhibitors ('statins') are being increasingly prescribed for the prevention of cardiovascular disease, this case report describes adverse effects of statin therapy which can sometimes be fatal. It highlights the need for physicians to be aware of individual patient risk factors predisposing to statin induced myopathy. It also highlights the need for further research into cholesterol lowering drugs which do not have such side effects. When prescribing statins for patients, we must also explain potential side effects following initiation of therapy and with dose titrations.
Related Concept Videos
Lipid-Lowering Drugs: Statins and Miscellaneous Agents
Hepatic Drug Clearance: Effect of Protein Binding
For low-extraction-ratio drugs that are less than 80% protein-bound, minor changes in protein binding...
Drug toxicity: Idiosyncratic Reactions
Renal Drug Excretion: Tubular Secretion
Nephrotic Syndrome II : Assessment and Medical Management
Drug toxicity: Drug–Drug Interaction
