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Updated: May 21, 2026

A 3D Organotypic Melanoma Spheroid Skin Model

A 3D Organotypic Melanoma Spheroid Skin Model

Published on: May 18, 2018

Symptomatic malignant melanoma presenting as multiple gastrointestinal polyps.

Shauna Casey¹, Lee Dvorkin, Nazar Alsanjari

¹Department of Cellular Pathology, NHS Basildon University Hospital, Basildon, UK. shaunacasey_2003@hotmail.com

BMJ Case Reports

|June 21, 2012

Summary

A 66-year-old man with gout developed nausea, diarrhea, and weight loss. Endoscopy revealed multiple malignant melanoma polyps throughout his gastrointestinal tract, leading to metastatic lung disease and palliative care referral.

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Last Updated: May 21, 2026

A 3D Organotypic Melanoma Spheroid Skin Model

A 3D Organotypic Melanoma Spheroid Skin Model

Published on: May 18, 2018

Area of Science:

Gastroenterology
Oncology
Pathology

Background:

A 66-year-old male with a history of gout presented with gastrointestinal symptoms.
Symptoms included nausea, intermittent diarrhea, and significant unintentional weight loss over six months.

Observation:

Initial assessment revealed anemia.
Diagnostic procedures, including gastroscopy and colonoscopy, identified multiple polyps in the stomach, duodenum, and colon.

Findings:

Histopathological examination confirmed all polyps were malignant melanoma.
The patient had no prior history of melanoma.
Staging computed tomography (CT) scan indicated widespread lung metastases.

Implications:

This case highlights a rare presentation of primary gastrointestinal malignant melanoma.
The findings underscore the importance of thorough gastrointestinal evaluation in patients with unexplained symptoms and anemia.
Early diagnosis and prompt management are crucial for potentially improving outcomes in rare oncological presentations.