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COPD: Management Using Bronchodilators and Corticosteroids01:26

COPD: Management Using Bronchodilators and Corticosteroids

Chronic obstructive pulmonary isease (COPD) involves a group of progressive lung disorders characterized by persistent airflow limitation and chronic respiratory symptoms. Asthma-COPD Overlap Syndrome (ACOS), encompassing features of both asthma and Chronic obstructive pulmonary disease (COPD), is a group of progressive lung disorders that includes chronic bronchitis, emphysema, and refractory (non-reversible) asthma. ACOS leads to complex clinical presentations that combine the inflammatory...
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Chronic Obstructive Pulmonary Disease-II: Pathophysiology01:20

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Chronic Inflammation
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Chronic bronchitis is a key phenotype of chronic obstructive pulmonary disease (COPD), characterized by airway-centered inflammation and mucus overproduction. It develops from long-term exposure to harmful particles or gases, most commonly cigarette smoke, which triggers a persistent inflammatory response.Cellular and Structural ChangesInflammation initially affects the large bronchi and later the smaller airways, with infiltration by immune cells, including neutrophils, macrophages, and...
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Chronic obstructive pulmonary disease is a common, preventable, and treatable respiratory disorder characterized by persistent symptoms and progressive airflow limitation. This limitation results from a combination of small-airway disease (obstructive bronchiolitis) and parenchymal destruction (emphysema), both driven by chronic inflammation from exposure to harmful particles or gases.The disease includes two main pathological entities: emphysema, marked by destruction of alveolar walls and...
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Asthma is a chronic inflammatory disorder of the airways characterized by variable airflow obstruction and heightened bronchial responsiveness to a wide range of triggers. The underlying inflammation leads to airway swelling, mucus hypersecretion, and smooth muscle constriction, all of which narrow the airway lumen and impede airflow. Clinically, asthma presents with recurrent episodes of wheezing, shortness of breath, chest tightness, and coughing, symptoms that typically vary in intensity and...

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Asthma and COPD - The C/EBP Connection.

Nicola Miglino1, Michael Roth, Michael Tamm

  • 1Pulmonary Cell Research, Departments of Biomedicine and Pneumology, University Hospital Basel, Switzerland.

The Open Respiratory Medicine Journal
|June 21, 2012
PubMed
Summary
This summary is machine-generated.

Asthma and COPD pathologies may stem from imbalanced CCAAT/Enhancer Binding Proteins (C/EBPs). Environmental factors alter C/EBP responses in diseased lung cells, offering new therapeutic targets.

Keywords:
AsthmaCCAAT-enhancer binding proteins.COPDairway inflammationairway wall remodelling

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Area of Science:

  • Pulmonary Medicine
  • Molecular Biology
  • Immunology

Background:

  • Asthma and COPD are prevalent chronic inflammatory lung diseases.
  • Airway remodeling is a common feature in both asthma and COPD.
  • The role of CCAAT/Enhancer Binding Proteins (C/EBPs) in these diseases is not fully understood.

Purpose of the Study:

  • To review the role of C/EBPs in the pathogenesis of asthma and COPD.
  • To explore how environmental factors influence C/EBP function in lung diseases.
  • To propose C/EBPs as potential therapeutic targets for asthma and COPD.

Main Methods:

  • Literature review of studies on C/EBPs, asthma, and COPD.
  • Analysis of the impact of environmental factors on C/EBP regulation.
  • Postulation of C/EBP dysregulation as a unifying mechanism.

Main Results:

  • C/EBP family proteins are crucial regulators of cell differentiation.
  • Inadequate C/EBP responses or imbalanced regulation may underlie asthma and COPD pathologies.
  • Environmental exposures like house dust mite and cigarette smoke differentially affect C/EBP function in diseased cells.

Conclusions:

  • C/EBP dysregulation is a potential key factor in asthma and COPD development.
  • Understanding C/EBP alterations provides novel insights into disease etiology.
  • Targeting C/EBPs may offer new therapeutic strategies for chronic inflammatory lung diseases.