Related Experiment Video
Updated: May 21, 2026
06:08
Quantification of Hypopigmentation Activity In Vitro
Published on: March 6, 2019
Approaches to the evaluation of lip hyperpigmentation
Vasanop Vachiramon1, Amy J McMichael
1Division of Dermatology, Faculty of Medicine, Ramathibodi Hospital, Mahidol University, Bangkok, Thailand.
International Journal of Dermatology
|June 22, 2012
Summary
Lip hyperpigmentation is common and linked to many conditions. This review offers a clinical algorithm to diagnose and manage these pigmented lip lesions based on presentation and patient factors.
Area of Science:
- Dermatology
- Oral Medicine
Background:
- Lip hyperpigmentation presents as a common dermatological concern.
- It is associated with diverse etiologies, including physiological changes, genetic disorders, inflammatory conditions, endocrine issues, drug reactions, and neoplasms.
- Accurate diagnosis is crucial for appropriate management.
Purpose of the Study:
- To present a clinical approach for diagnosing lip hyperpigmentation.
- To offer an algorithm for guiding diagnosis and therapeutic planning for pigmented lip lesions.
- To consolidate information on the varied causes of lip hyperpigmentation.
Main Methods:
- Review of literature on lip hyperpigmentation.
- Development of a diagnostic and therapeutic algorithm based on clinical presentation.
- Consideration of lesion extent, age of onset, and systemic associations.
Main Results:
- A structured algorithm is proposed to aid in the diagnosis of pigmented lip lesions.
- The algorithm integrates clinical features such as lesion characteristics and patient history.
- Differential diagnosis considers a broad spectrum of underlying causes.
Conclusions:
- A systematic clinical approach can effectively manage lip hyperpigmentation.
- The proposed algorithm provides a framework for diagnosis and treatment planning.
- Further research may be needed to validate findings from case reports and small series.
Related Concept Videos
01:30Skin Cancer
Skin cancer is a type of cancer that occurs when there is an abnormal growth of skin cells, usually triggered by damage to the DNA within the skin cells. It is primarily caused by exposure to ultraviolet (UV) radiation from the sun or artificial sources like tanning beds. Skin cancer is the most common type of cancer worldwide, and its incidence continues to rise.
Basal Cell Carcinoma (BCC): BCC is the most common type of skin cancer, accounting for about 80% of cases. It typically develops in...
Basal Cell Carcinoma (BCC): BCC is the most common type of skin cancer, accounting for about 80% of cases. It typically develops in...
01:14Changes in Skin Color: Clinical Perspectives
The first thing a clinician sees is the skin, so the examination of the skin should be part of any thorough physical examination. Most skin disorders are relatively benign, but a few, including melanomas, can be fatal if untreated. A couple of the more noticeable disorders, albinism and vitiligo, affect the appearance of the skin and its accessory organs.
Albinism
Albinism is a genetic disorder that affects (completely or partially) the coloring of skin, hair, and eyes. The defect is primarily...
Albinism
Albinism is a genetic disorder that affects (completely or partially) the coloring of skin, hair, and eyes. The defect is primarily...
01:19Pigmentation
The color of the skin is influenced by a number of pigments, including melanin, carotene, and hemoglobin. Recall that melanin is produced by cells called melanocytes, which are found scattered throughout the stratum basale of the epidermis. The melanin is transferred to the keratinocytes via melanosomes.
Melanin occurs in two primary forms: eumelanin that provides black and brown pigment and pheomelanin that provides red color. Dark-skinned individuals produce more melanin than those with pale...
Melanin occurs in two primary forms: eumelanin that provides black and brown pigment and pheomelanin that provides red color. Dark-skinned individuals produce more melanin than those with pale...