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Related Experiment Video

Updated: May 21, 2026

A Novel Cell Injection Method with Minimum Invasion

A Novel Cell Injection Method with Minimum Invasion

Published on: April 21, 2023

Using cold air for reducing needle-injection pain.

Firas Al-Qarqaz¹, Mustafa Al-Aboosi, Diala Al-shiyab

¹Department of Dermatology, Jordan University of Science and Technology, Irbid, Jordan. faalqarqaz@yahoo.com

International Journal of Dermatology

|June 22, 2012

Summary

Cold air application effectively reduces needle-injection pain for most patients, particularly in sensitive areas like the palms. This safe method offers a new way to manage discomfort during skin injections.

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Area of Science:

Dermatology
Pain Management
Medical Device Technology

Background:

Injection-associated pain is a significant concern, especially for procedures requiring multiple injections in areas like the palms.
Minimizing pain during injections is crucial for patient comfort and compliance.
A novel application of cold air, typically used in laser therapy, is explored for pain reduction.

Purpose of the Study:

To evaluate the efficacy of cold air in reducing pain associated with skin injections.
To assess the safety profile of this new cold air application for pain management.

Main Methods:

A study involving 40 patients undergoing skin injections was conducted.
Pain levels were assessed using the Visual Analog Scale (VAS) with and without cold air application in the same patient.
Pain scores were compared to determine the effect of cold air.

Main Results:

A majority of patients (33 out of 40) reported lower VAS scores when cold air was used.
Patients receiving injections in the palms experienced even greater pain reduction.
No significant immediate or delayed adverse side effects were observed.

Conclusions:

Cold air application demonstrates utility in alleviating needle-injection pain for most patients.
The procedure is considered safe, with only minor, tolerable discomfort reported around the nose.
This method shows particular promise for pain management in sensitive anatomical regions like the palms.