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Pazopanib in the treatment of soft tissue sarcoma

Patrick Schöffski1

  • 1Department of General Medical Oncology & Laboratory of Experimental Oncology, University Hospitals Leuven, Leuven Cancer Institute, Catholic University Leuven, Leuven, Belgium. patrick.schoffski@uzleuven.be

Expert Review of Anticancer Therapy
|June 22, 2012
PubMed

Insights

Pazopanib, a novel multi-tyrosine kinase inhibitor, shows promise for advanced soft tissue sarcoma (STS) patients. Clinical trials demonstrate pazopanib significantly improves progression-free survival in various STS subtypes.

Area of Science:

  • Oncology
  • Pharmacology

Background:

  • Advanced metastatic soft tissue sarcoma (STS) presents a poor prognosis with limited survival improvements over recent decades.
  • There is a critical need for novel therapeutic strategies to improve outcomes and prevent metastasis in STS patients.

Purpose of the Study:

  • To evaluate the efficacy and safety of pazopanib in patients with advanced metastatic soft tissue sarcoma.
  • To assess pazopanib's impact on progression-free survival and tumor growth in diverse STS subtypes.

Main Methods:

  • Phase II and III clinical trials were conducted to assess pazopanib's activity in advanced STS.
  • Pazopanib, a multi-tyrosine kinase inhibitor, was administered to patients with various STS subtypes.

Main Results:

  • Pazopanib demonstrated significant activity in Phase II studies across leiomyosarcomas, synovial sarcomas, and other eligible STS.
  • A Phase III trial confirmed pazopanib's efficacy, showing a significant extension in median progression-free survival compared to placebo in multiple STS subtypes.

Conclusions:

  • Pazopanib is an active agent for advanced soft tissue sarcoma, offering a new treatment option.
  • The findings support pazopanib's role in improving progression-free survival for patients with advanced STS.

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