Related Experiment Videos
Enantioselective oxidations of sulfides catalyzed by chloroperoxidase
S Colonna1, N Gaggero, A Manfredi
1Dipartimento di Chimica Organica e Industriale, Università di Milano, Italy.
Biochemistry
|November 20, 1990
Abstract:
The chloroperoxidase-catalyzed and horseradish peroxidase catalyzed oxidations of sulfides by tert-butyl and other peroxides have been investigated. The former metal enzyme afforded the corresponding sulfoxides having R absolute configuration in up to 92% enantiomeric excess (ee), whereas the latter gave racemic products. The various factors that control the enantioselectivity of the oxygenation have been examined.