Related Experiment Video
Updated: May 21, 2026

An In Vivo Estrogen Deficiency Mouse Model for Screening Exogenous Estrogen Treatments of Cardiovascular Dysfunction After Menopause
Published on: August 13, 2019
DHEA for poor responders: can treatment be justified in the absence of evidence?
Abstract:
Evidence-based medicine is the application of science to the practice of healthcare, leading to reproducibility and transparency in the science supporting healthcare practice. Dehydroepiandrosterone (DHEA) has been proposed as a treatment for improving ovarian reserve in poor responding women undergoing IVF. However, there is a lack of evidence of its effectiveness as data is derived mostly from retrospective studies and one questionable randomized trial. DHEA appears to be devoid of major side effects, however, due lack of data supporting its effectiveness, its wide scale use cannot be currently recommended.
Related Concept Videos
Dose-Response Relationship: Overview
Dose-Response Relationship: Potency and Efficacy
Effect of Hepatic Disease on Pharmacokinetics: Dose Adjustments Due to Hepatic Impairment
Dose-Response Relationship: Selectivity and Specificity
Factors Affecting Drug Response: Overview
Bioequivalence of Drugs: Drugs with Multiple Indications