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Updated: May 21, 2026

Systematic Assessment of Mammalian Skull Specimens for Dental and Temporomandibular Joint Pathology

Systematic Assessment of Mammalian Skull Specimens for Dental and Temporomandibular Joint Pathology

Published on: August 22, 2022

Is there pathology associated with asymptomatic third molars?

Robert D Marciani¹

¹Division of Oral and Maxillofacial Surgery, University of Cincinnati, Cincinnati, OH, USA. tbdodson@partners.org

Journal of Oral and Maxillofacial Surgery : Official Journal of the American Association of Oral and Maxillofacial Surgeons

|June 22, 2012

Summary

Asymptomatic third molars (M3s) can harbor disease. Regular dental exams are crucial for detecting pathology in retained M3s before symptoms arise.

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Last Updated: May 21, 2026

Systematic Assessment of Mammalian Skull Specimens for Dental and Temporomandibular Joint Pathology

Systematic Assessment of Mammalian Skull Specimens for Dental and Temporomandibular Joint Pathology

Published on: August 22, 2022

Area of Science:

Dentistry
Periodontology
Oral Surgery

Background:

Third molars (M3s) are frequently retained, and their asymptomatic status may mask underlying pathology.
Understanding the long-term health risks associated with retained M3s is essential for patient management.

Purpose of the Study:

To estimate the prevalence of disease in asymptomatic third molars (M3s) at baseline.
To assess the long-term health risks associated with retaining M3s.

Main Methods:

A comprehensive literature search was performed using Google Scholar.
Included studies were prospective with over 50 subjects and a follow-up exceeding 1 year.
Search terms focused on third molars and associated pathologies like periodontitis, pericoronitis, caries, and infections.

Main Results:

Periodontal pathology was linked to asymptomatic M3s, with 25% of subjects showing signs of disease.
Deeper probing depths (PD ≥ 5 mm) in the M3 region correlated with significant attachment loss.
Early clinical and microbial changes indicative of periodontitis were observed in the M3 region of young adults.

Conclusions:

Asymptomatic third molars (M3s) can present with significant disease.
Regular clinical and radiographic examinations are recommended for patients retaining M3s to detect pathology early.