Related Experiment Videos
Adverse effects of inhaled corticosteroids
1Chest Clinic, Guy's Hospital, UMDS, London, UK.
Biomedicine & Pharmacotherapy = Biomedecine & Pharmacotherapie
|January 1, 1990
Summary
New synthetic inhaled corticosteroids offer effective asthma management with fewer side effects than oral steroids. While some side effects like oral candidiasis and potential adrenal suppression exist, they are generally manageable.
Area of Science:
- Pulmonology
- Pharmacology
Background:
- Corticosteroids are crucial for asthma management due to their anti-inflammatory properties.
- Oral corticosteroids cause significant side effects, limiting their long-term use.
- Previous strategies to mitigate side effects were largely unsuccessful.
Purpose of the Study:
- To evaluate the efficacy and safety of new synthetic inhaled corticosteroids for asthma control.
- To assess the side effect profile of these novel inhaled corticosteroids.
Main Methods:
- Review of recent synthetic corticosteroid development and clinical data.
- Analysis of reported side effects including oral candidiasis, adrenal suppression, and bone turnover.
- Evaluation of treatment strategies for managing side effects.
Main Results:
- New synthetic inhaled corticosteroids provide effective airway obstruction control in most asthma patients.
- Common side effects include oral candidiasis, manageable with dosage adjustments and delivery system changes.
- Biochemical evidence of adrenal suppression and effects on bone turnover indices exist at high doses, but long-term clinical significance is under evaluation.
Conclusions:
- Inhaled corticosteroids represent a significant advancement in asthma management.
- Physicians must remain vigilant for potential systemic side effects, especially with high-dose, long-term use.
- Further research is needed to clarify the long-term clinical implications of observed biochemical changes.