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Related Experiment Video

Updated: May 21, 2026

Rapid Detection of Neurodevelopmental Phenotypes in Human Neural Precursor Cells (NPCs)
10:47

Rapid Detection of Neurodevelopmental Phenotypes in Human Neural Precursor Cells (NPCs)

Published on: March 2, 2018

Modeling neurodevelopmental disorders using human neurons.

Thanathom Chailangkarn1, Allan Acab, Alysson Renato Muotri

  • 1University of California San Diego, School of Medicine, Department of Pediatrics/Rady Children's Hospital San Diego, Department of Cellular & Molecular Medicine, Stem Cell Program, La Jolla, CA 92093, USA.

Current Opinion in Neurobiology
|June 22, 2012
PubMed
Summary
This summary is machine-generated.

Induced pluripotent stem cell (iPSC) technology enables the creation of patient-specific neurons, overcoming a major research barrier. This approach shows promise for understanding neurodevelopmental disorders like autism spectrum disorder and developing new therapeutics.

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Last Updated: May 21, 2026

Rapid Detection of Neurodevelopmental Phenotypes in Human Neural Precursor Cells (NPCs)
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10:53

Generation of Human Neurons and Oligodendrocytes from Pluripotent Stem Cells for Modeling Neuron-Oligodendrocyte Interactions

Published on: November 9, 2020

Area of Science:

  • Neuroscience
  • Stem Cell Biology
  • Genetics

Background:

  • Neurodevelopmental disorders, including autism spectrum disorders, lack accessible patient-specific cellular models for research.
  • Understanding the cellular and molecular underpinnings of these conditions has been hindered by the unavailability of live patient neurons.

Purpose of the Study:

  • To review the application of induced pluripotent stem cell (iPSC) technology in modeling neurodevelopmental disorders.
  • To discuss the potential and limitations of iPSC-based disease modeling and drug screening.
  • To highlight the promise of iPSC technology for understanding autism spectrum disorders and developing treatments.

Main Methods:

  • Generation of human neurons from patient-derived induced pluripotent stem cells (iPSCs).
  • Utilizing iPSC-derived neurons to model neurodevelopmental conditions in vitro.
  • Reviewing current research and findings from studies employing iPSC technology for disease modeling.

Main Results:

  • Reproducible disease-relevant phenotypes have been observed in neurons derived from Rett syndrome patients' iPSCs.
  • iPSC technology provides a viable method for creating patient-specific neuronal models.
  • The approach facilitates the study of cellular and molecular mechanisms in neurodevelopmental disorders.

Conclusions:

  • Induced pluripotent stem cell technology offers a novel and unique opportunity to study neurodevelopmental disorders.
  • This technology holds significant potential for advancing the understanding and therapeutic development for autism spectrum disorders.
  • iPSC-derived neurons can serve as a valuable platform for disease modeling and drug discovery.