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Establishment of an Embryo Implantation Model In Vitro
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Cell adhesion molecules in human embryo implantation

Michiko N Fukuda1, Kazuhiro Sugihara

  • 1Cancer Center, Sanford-Burnham Medical Research Institute, La Jolla, CA, USA. michiko@burnham.org

Sheng Li Xue Bao : [Acta Physiologica Sinica]
|June 22, 2012
PubMed

The process of human embryo implantation is mediated not only by evolutionarily conserved mechanisms, but also by a mechanism unique to humans. Evidence suggests that the cell adhesion molecules, L-selectin and trophinin, play a unique role in human embryo implantation. Here, we describe the dual roles of mucin carbohydrate ligand for L-selectin and trophinin protein and of the trophinin-associated proteins bystin and tastin. We then describe trophinin-mediated signal transduction in trophectoderm cells and endometrial epithelial cells. This review also covers cadherin and integrin in human embryo implantation.

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