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Updated: May 21, 2026

Comparing Metastatic Clear Cell Renal Cell Carcinoma Model Established in Mouse Kidney and on Chicken Chorioallantoic Membrane
Published on: February 8, 2020
Novel germline c-MET mutation in a family with hereditary papillary renal carcinoma
Karin A W Wadt1, Anne-Marie Gerdes, Thomas V O Hansen
1Department of Clinical Genetics, Rigshospitalet, Blegdamsvej 9, 2100, Copenhagen, Denmark. karin.wadt@rh.regionh.dk
Abstract:
Hereditary papillary renal carcinoma (HPRC) is a highly penetrant hereditary renal cancer syndrome caused by germline missense mutations in the c-MET proto-oncogene. HPRC is clinically characterized by multiple bilateral papillary renal-cell carcinomas. Here we report a family with a novel missense mutation in c-MET. The original pathology report of four primary kidney cancers (1988-1997) revealed renal-cell carcinoma. A revised report described multiple adenomas and papillary renal-cell carcinomas with focal clear cells and a mixture of type 1 and type 2 pattern, emphasizing the importance of revised pathology examinations in possible hereditary renal-cell carcinomas especially when described before 1997.
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