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Updated: May 21, 2026

Isolation of Murine Lymph Node Stromal Cells
Published on: August 19, 2014
Lymph node vascular-stromal growth and function as a potential target for controlling immunity
Fairouz Benahmed1, Scott Ely, Theresa T Lu
1Autoimmunity and Inflammation Program, Hospital for Special Surgery, New York, NY 10021, USA. BenahmedF@hss.edu
Abstract:
Lymphadenopathy occurs in many autoimmune and inflammatory diseases, and vascular proliferation is a common feature in the enlarged lymph nodes. The lymph node vasculature plays critical roles in delivering immune cells as well as oxygen and micronutrients, and therefore represents a potential target for therapeutic manipulation of immunity. In this review, we discuss recent insights made in understanding the growth and function of the vascular and associated stromal compartment in immune-stimulated lymph nodes and the potential utility of altering this process in autoimmune diseases.
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