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Post-transfusion malaria in thalassaemia patients
N J Choudhury1, M L Dubey, J G Jolly
1Department of Blood Transfusion and Immunohaematology, Postgraduate Institute of Medical Education and Research, Chandigarh, India.
Blut
|November 1, 1990
Summary
Post-transfusion malaria (PTM) affects 6.4% of beta-thalassaemia patients due to frequent transfusions. Antigen detection is a more sensitive method for diagnosing PTM and screening blood donors for malaria.
Area of Science:
- Hematology
- Infectious Diseases
- Transfusion Medicine
Background:
- Beta-thalassaemia patients require frequent blood transfusions.
- Blood transfusions can transmit infections, including malaria.
- Post-transfusion malaria (PTM) is a significant concern in transfusion-dependent populations.
Purpose of the Study:
- To investigate the incidence of PTM in beta-thalassaemia patients.
- To compare diagnostic methods for PTM.
- To evaluate blood donor screening for malaria.
Main Methods:
- Screening of 125 beta-thalassaemia patients for malaria using Giemsa stain, Acridine-orange stain, and antigen detection.
- Tracing infected blood donors to confirm PTM.
- Comparing the sensitivity of diagnostic methods.
Main Results:
- 8 out of 125 (6.4%) patients developed PTM.
- PTM incidence is linked to fresh blood use and high transfusion frequency.
- Antigen detection demonstrated higher sensitivity than blood smear methods for PTM diagnosis and donor screening.
Conclusions:
- Antigen detection is recommended for routine blood donor screening to prevent PTM.
- Improved malaria screening in blood donors is crucial for beta-thalassaemia patients.
- Further research into transfusion-transmitted malaria in vulnerable populations is warranted.