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Transcytosis of IgG

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Transcytosis is the process in which molecules are internalized by endocytosis, transported across the cell, and released through exocytosis from the opposite end of the cell. Molecules such as insulin, immunoglobulins, and certain nutrients are transferred through the recycling endosomes by recycling and transcytosis.
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Updated: May 21, 2026

Mouse In Vivo Placental Targeted CRISPR Manipulation

Mouse In Vivo Placental Targeted CRISPR Manipulation

Published on: April 14, 2023

HLA class I expression in the human placenta.

Herbert Juch¹, Astrid Blaschitz, Gottfried Dohr

¹Institute of Cell Biology, Histology and Embryology, Center for Molecular Medicine, Medical University of Graz, Graz, Austria.

Wiener Medizinische Wochenschrift (1946)

|June 22, 2012

Summary

This summary is machine-generated.

Pregnancy involves deep invasion of placental cells into the uterus, requiring maternal immune tolerance. Unique human leukocyte antigen (HLA) class I expression on trophoblast cells is key to this fascinating immune challenge.

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Immunopeptidomics: Isolation of Mouse and Human MHC Class I- and II-Associated Peptides for Mass Spectrometry Analysis

Immunopeptidomics: Isolation of Mouse and Human MHC Class I- and II-Associated Peptides for Mass Spectrometry Analysis

Published on: October 15, 2021

Area of Science:

Reproductive immunology
Maternal-fetal interface biology
Human immune system research

Background:

Pregnancy involves semi-allogeneic placental trophoblast cells invading maternal uterine tissue.
Maternal immune tolerance is crucial for fetal growth and development.
The unique expression of human leukocyte antigen (HLA) class I molecules on trophoblast cells is a significant factor.

Purpose of the Study:

To explore the role of HLA class I expression in maternal immune tolerance during pregnancy.
To understand pregnancy not as an immunologic paradox but as a unique immune challenge.
To investigate the mechanisms underlying the maternal immune system's acceptance of the semi-allogeneic fetus.

Main Methods:

Analysis of placental trophoblast cell invasion patterns.
Immunological assessment of the maternal-fetal interface.
Comparative study of HLA class I expression in pregnancy versus organ transplantation.

Main Results:

Trophoblast cells exhibit unique HLA class I expression patterns.
This unique expression is proposed as a key mechanism for immune tolerance.
Pregnancy presents distinct immunological challenges compared to organ transplantation.

Conclusions:

The extraordinary HLA class I expression on trophoblast cells is central to successful pregnancy.
Pregnancy is a specialized immunological adaptation, not an inherent paradox.
Understanding this unique immune interaction is vital for reproductive health research.