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Flow cytometry: clinical applications in haematology
Bailliere'S Clinical Haematology
|October 1, 1990
Summary
New clinical hematology methods, like flow cytometry for reticulocyte counting, face long adoption times. This review highlights promising techniques for clinical hematology and quality control essentials.
Area of Science:
- Clinical Hematology
- Medical Technology Assessment
Background:
- Clinical adoption of new methodologies often spans many years.
- Flow cytometry for reticulocyte counting, for instance, took 8 years to progress from initial publication.
Purpose of the Study:
- To review emerging methodologies with potential clinical hematology applications.
- To provide practical details on recently validated clinical laboratory methods.
Main Methods:
- Review of techniques for leukocyte enumeration, bone marrow studies, neutrophil analysis, platelet analysis, and cellular DNA content.
- Examination of reticulocyte counting and total red cell volume measurement.
- Discussion of flow cytometry's role in immunophenotyping hematological disorders.
Main Results:
- Flow cytometry is highlighted as a clinically acceptable method for immunophenotyping hematological disorders.
- Methods with potential clinical applications in hematology are categorized.
- Practical aspects of viable new clinical laboratory methods are detailed.
Conclusions:
- Anticipating the clinical acceptance of new methodologies is challenging due to long adoption timelines.
- Quality control is a critical prerequisite for adopting new methods in clinical laboratories.
- Flow cytometry has demonstrated significant clinical utility in hematological disorder immunophenotyping.