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Polyherbal preparation for anti-diabetic activity: a screening study
Noopur Srivastava1, Gaurav Tiwari, Ruchi Tiwari
1Department of Pharmaceutical Sciences, Bhagwant University, Sikar Road, Ajmer, India.
Indian Journal of Medical Sciences
|June 22, 2012
Summary
This study screened a polyherbal preparation for anti-diabetic activity. The preparation significantly lowered blood glucose in normal and diabetic rats, showing promise for diabetes management.
Area of Science:
- Pharmacology
- Natural Product Chemistry
- Diabetology
Background:
- Diabetes mellitus is a global health concern requiring effective and accessible treatments.
- Polyherbal preparations, combining multiple medicinal plants, offer potential synergistic therapeutic effects.
- Wheat germ oil, Coriandrum sativum, and Aloe vera are traditional remedies with purported health benefits.
Purpose of the Study:
- To evaluate the anti-diabetic efficacy of a novel polyherbal preparation in a rat model.
- To screen the blood glucose-lowering activity of different formulations of the polyherbal preparation.
- To assess the safety and efficacy of the preparation in both normal and alloxan-induced diabetic rats.
Main Methods:
- Three polyherbal preparations (I, II, III) with varying ratios of Wheat germ oil, Coriandrum sativum, and Aloe vera were formulated.
- Blood glucose levels were measured in normal rats and alloxan-induced diabetic rats following oral administration of the preparations.
- Glucose levels were monitored over specific time intervals using the GOD/POD method and analyzed statistically.
Main Results:
- Polyherbal preparation-I demonstrated a significant reduction in blood glucose levels in normal rats.
- All three polyherbal preparations (I, II, and III) significantly reduced blood glucose levels in diabetic rats over a 30-day study period.
- The observed reductions were statistically significant when compared to control groups and the standard anti-diabetic drug, Glibenclamide.
Conclusions:
- The polyherbal preparation exhibits significant anti-diabetic properties, effectively lowering blood glucose in both normal and diabetic conditions.
- The findings suggest that this polyherbal preparation is a promising candidate for the development of affordable anti-diabetic treatments for the general population.
- Further extensive clinical studies in humans are warranted to confirm the efficacy and safety of this preparation for widespread use.
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