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Identifying Dysregulated Genes Induced by Kaposi's Sarcoma-associated Herpesvirus (KSHV)

Identifying Dysregulated Genes Induced by Kaposi's Sarcoma-associated Herpesvirus (KSHV)

Published on: September 14, 2010

Aggressive classical Kaposi's sarcoma mimicking malignant lymphoma.

Eun Haeng Jeong¹, Dong Hoe Koo, Sang Hyuk Lee

¹Department of Internal Medicine, Kangbuk Samsung Hospital, Sungkyunkwan University School of Medicine, 108 Pyung-Dong, Chongno-Gu, Seoul, 110-746, South Korea.

Pathology Oncology Research : POR

|June 22, 2012

Summary

Classical Kaposi's sarcoma (KS) rarely disseminates to visceral lymph nodes. This aggressive case mimicked lymphoma, highlighting the need for vigilance in diagnosing unusual KS presentations.

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Published on: September 14, 2010

An In Vitro Model for Studying Cellular Transformation by Kaposi Sarcoma Herpesvirus

An In Vitro Model for Studying Cellular Transformation by Kaposi Sarcoma Herpesvirus

Published on: August 25, 2017

Area of Science:

Oncology
Pathology

Background:

Classical Kaposi's sarcoma (KS) is typically a slow-growing vascular neoplasm.
Visceral lymph node involvement in classical KS is exceptionally rare, often associated with HIV/AIDS.

Observation:

A 72-year-old woman presented with constitutional symptoms and skin lesions.
Rapidly progressing cytopenias and widespread lymphadenopathy were noted.
Imaging revealed disseminated lymphadenopathy across multiple nodal basins.

Findings:

Inguinal lymph node biopsy confirmed Kaposi's sarcoma.
Immunohistochemical stains were positive for CD31, CD34, and human herpesvirus-8.
The clinical presentation mimicked aggressive malignant lymphoma.

Implications:

This case underscores the potential for aggressive behavior in classical KS.
It highlights the importance of considering KS in the differential diagnosis of disseminated lymphadenopathy, even in non-HIV patients.
Accurate diagnosis is crucial for appropriate management and treatment strategies.