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Multiplex sibling history of coronary heart disease is a strong risk factor for coronary heart disease

Bengt Zöller1, Xinjun Li, Jan Sundquist

  • 1Center for Primary Health Care Research, Lund University/Region Skåne, Skåne University Hospital, CRC, Building 28, Floor 11, Entrance 72, SE-205 02 Malmö, Sweden. bengt.zoller@med.lu.se

European Heart Journal
|June 22, 2012
PubMed

Insights

A family history of multiple siblings affected by coronary heart disease (CHD) significantly increases an individual's risk. This risk escalates with each additional affected sibling, indicating a graded familial predisposition to CHD.

Area of Science:

  • Cardiovascular Epidemiology
  • Genetics of Heart Disease
  • Public Health

Background:

  • Familial aggregation of coronary heart disease (CHD) is recognized, but risks in families with multiple affected siblings require further investigation.
  • Understanding these risks is crucial for identifying high-risk individuals and families.

Purpose of the Study:

  • To quantify the familial risk of hospitalization or death due to coronary heart disease (CHD) in individuals with multiple affected siblings.
  • To determine if the risk of CHD increases with the number of affected siblings in a family.

Main Methods:

  • A nationwide cohort study utilizing Swedish Multigeneration Register data linked to hospitalization and death records (1964-2008).
  • Standardized incidence ratios (SIRs) were calculated for siblings and spouses of individuals hospitalized or deceased due to CHD.
  • Comparison groups included individuals with unaffected siblings.

Main Results:

  • Siblings of affected individuals had a 1.82-fold increased risk of CHD hospitalization and a 1.60-fold increased risk of CHD death.
  • The risk of CHD hospitalization and death significantly increased with two or three affected siblings, with SIRs ranging from 6.61 to 7.88.
  • Spouses showed minimal familial risk (SIR = 1.05).

Conclusions:

  • A family history of multiple affected siblings is a significant risk factor for coronary heart disease (CHD).
  • CHD risk is not a simple binary trait but demonstrates a dose-response relationship with the number of affected siblings.
  • These findings highlight the importance of detailed family history in assessing individual CHD risk.
Abstract

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