Related Experiment Video

Updated: May 21, 2026

Upper-extremity Approach for Secondary Access in Transfemoral Transcatheter Aortic Valve Implantation
06:04

Upper-extremity Approach for Secondary Access in Transfemoral Transcatheter Aortic Valve Implantation

Published on: August 8, 2025

Colombian experience with transcatheter aortic valve implantation of medtronic CoreValve

Antonio E Dager1, Rutger-Jan Nuis, Bernardo Caicedo

  • 1Department of Cardiology, Angiografia de Occidente, Cali, Colombia.

Texas Heart Institute Journal
|June 22, 2012
PubMed

Insights

Transcatheter Aortic Valve Implantation (TAVI) is safe and feasible for high-risk aortic stenosis patients. While serious adverse events occurred in 30%, TAVI demonstrated sustained long-term results.

Area of Science:

  • Cardiology
  • Interventional Cardiology
  • Cardiac Surgery

Background:

  • A growing number of patients with aortic stenosis are unsuitable for surgical aortic valve replacement.
  • This led to the initiation of the Cali Colombian Transcatheter Aortic Valve Implantation (TAVI) program.

Purpose of the Study:

  • To evaluate the clinical outcomes and safety of TAVI using the Medtronic CoreValve System in patients with severe aortic stenosis who are at excessive surgical risk.
  • To report the early and 1-year results of the first consecutive patients treated in the Cali Colombian TAVI program.

Main Methods:

  • Prospective data collection from 53 consecutive patients (mean age 79 ± 6 years) undergoing TAVI with the Medtronic CoreValve System from March 2008 to January 2011.
  • Endpoints conformed to Valve Academic Research Consortium recommendations, including 30-day mortality, safety endpoints, and technical device success.
  • Hemodynamic parameters and regurgitation were assessed post-procedure.

Main Results:

  • Predicted mortality by logistic EuroSCORE was 25% and by STS score was 6%.
  • The 30-day mortality rate was 9%. The combined 30-day safety endpoint was met in 30% of patients, including major vascular sequelae (23%) and life-threatening bleeding (12%).
  • Technical device success was 77%. Significant improvements were observed in mean transvalvular gradients (74 to 17 mmHg) and mitral regurgitation (32% to 13%, P=0.002). The 1-year survival rate was 81%.

Conclusions:

  • TAVI with the CoreValve prosthesis is a safe and feasible option for treating aortic stenosis in patients deemed high-risk for surgical intervention.
  • The procedure demonstrated sustained long-term efficacy, although a significant proportion of patients experienced serious adverse events.
  • Careful patient selection and procedural management are crucial for optimizing TAVI outcomes.

Keywords:
Aortic valve stenosis/complications/mortality/surgerycomorbidityheart valve prosthesis implantation/methodspostoperative complications/etiology/prevention & controlregistriesrisk factorstreatment outcome

Related Concept Videos

Cardiac Catheterization II: Right Heart Catheterization01:21

Cardiac Catheterization II: Right Heart Catheterization

Right Heart Catheterization: An OverviewRight heart catheterization is an invasive diagnostic procedure that measures right-sided cardiac and pulmonary artery pressures, calculates cardiac output, and identifies intracardiac shunts. It provides detailed hemodynamic data essential for diagnosing and managing various cardiovascular conditions, such as pulmonary hypertension.Access SitesCommon access sites for right heart catheterization include the internal jugular vein in the neck region, the...
Cardiac Catheterization III: Left Heart Catheterization01:24

Cardiac Catheterization III: Left Heart Catheterization

Left heart catheterization is an invasive diagnostic procedure used to evaluate the function and structure of the left side of the heart. It is generally performed to diagnose and treat cardiovascular conditions such as valve abnormalities, coronary artery disease, and congenital heart defects.Diagnostic and therapeutic purposesLeft heart catheterization serves various diagnostic and therapeutic purposes, including:Assessing coronary artery bypass grafts.Evaluating coronary artery disease in...
Mitral Stenosis I: Introduction01:22

Mitral Stenosis I: Introduction

Mitral Valve Stenosis (MVS) is a heart condition where the mitral valve narrows, impeding blood circulation from the left atrium to the left ventricle. The etiology and pathophysiology of this condition are multifaceted, leading to a cascade of cardiovascular complications.Causes of Mitral Valve StenosisRheumatic Heart Disease: It is the main cause of mitral valve stenosis, particularly in developing nations. This condition arises from rheumatic fever, an inflammatory illness resulting from...
Cardiac Catheterization I: Pre-Procedure Overview01:28

Cardiac Catheterization I: Pre-Procedure Overview

Cardiac catheterization is an invasive diagnostic technique used to identify and evaluate structural and functional diseases of the heart and major blood vessels. This technique diagnoses congenital heart disease, coronary artery disease, valvular heart disease, and coronary spasms and assesses ventricular function. It helps guide treatment decisions, including the need for revascularization procedures like percutaneous coronary intervention (PCI) or coronary artery bypass grafting (CABG) and...
Mitral Valve Prolapse I: Introduction01:27

Mitral Valve Prolapse I: Introduction

IntroductionThe mitral valve, one of the heart's four valves, regulates blood flow. These valves have flaps that open and close to direct blood properly through the heart and body. During each heartbeat, the flaps open for blood to pass through and seal shut to prevent backflow. Specifically, the mitral valve opens to allow blood flow from the heart's upper left chamber to the lower left chamber. It then closes securely as the lower left chamber contracts to pump blood to the body, preventing...
Mitral Stenosis III: Medical Management01:26

Mitral Stenosis III: Medical Management

Mitral stenosis, a condition marked by the narrowing of the mitral valve, necessitates an integrated approach for effective management. This approach includes preventative measures, medical therapy, and surgical interventions to reduce symptoms and prevent complications.PreventionPrevention of mitral stenosis primarily focuses on reducing the incidence of bacterial infections, particularly streptococcal infections, which can lead to rheumatic fever and subsequent valvular damage. Timely...