Related Experiment Video
Updated: May 21, 2026

Synthesis and Bioconjugation of Thiol-Reactive Reagents for the Creation of Site-Selectively Modified Immunoconjugates
Published on: March 6, 2019
(E)-(2,4-Dichloro-benzyl-idene)amino cyclo-propane-carboxyl-ate
1College of Chemistry and Chemical Engineering, Beifang University of Nationalities, Yinchuan 750021, People's Republic of China.
Abstract:
In the title compound C(11)H(9)Cl(2)NO(2), the dihedral angle between the benzene and cyclo-propane ring planes is 89.95 (13)°. The carbon-yl-oxime grouping is almost coplanar with the benzene ring [dihedral angle = 4.08 (6)°]. In the crystal, mol-ecules are linked by C-H⋯O inter-actions into [100] chains.
More Related Videos
10:17Efficient Construction of Drug-like Bispirocyclic Scaffolds Via Organocatalytic Cycloadditions of α-Imino γ-Lactones and Alkylidene Pyrazolones
Published on: February 7, 2019
11:04Preparation of Enantiopure Non-Activated Aziridines and Synthesis of Biemamide B, D, and epiallo-Isomuscarine
Published on: June 13, 2022
Related Concept Videos
[4+2] Cycloaddition of Conjugated Dienes: Diels–Alder Reaction
Nomenclature of Primary Amines
Intramolecular Claisen Condensation of Dicarboxylic Esters: Dieckmann Cyclization
Carboxylic Acids to Methylesters: Alkylation using Diazomethane
Nomenclature of Carboxylic Acid Derivatives: Amides and Nitriles
The IUPAC and common names of amides are derived from the parent carboxylic acid, by replacing the suffix “oic acid” and “ic acid,” respectively, with “amide.” In the following example, the IUPAC name ethanamide is derived from ethanoic acid, and the common name, acetamide, is obtained from acetic acid.
Preparation of Amides
The DCC-promoted synthesis of amides begins with the protonation of DCC by carboxylic acid. The protonation makes it a better acceptor. Next, the addition of carboxylate to the protonated carbodiimide gives a reactive acylating agent.
Subsequently, the amine acts as a nucleophile that attacks the acylating agent to form a tetrahedral intermediate. In the...