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Updated: May 21, 2026

Preparation and In Vivo Use of an Activity-based Probe for N-acylethanolamine Acid Amidase
Published on: November 23, 2016
(E)-4-Amino-N'-(2-nitro-benzyl-idene)benzohydrazide
This study details the crystal structure of a Schiff base compound, C(14)H(12)N(4)O(3). Molecular analysis reveals an E conformation and planar structure, with hydrogen bonds forming layered crystal structures.
Area of Science:
- Crystallography
- Organic Chemistry
- Materials Science
Background:
- Schiff base compounds are versatile organic molecules with diverse applications.
- Understanding the solid-state structure is crucial for predicting material properties.
Purpose of the Study:
- To elucidate the crystal structure and intermolecular interactions of a novel Schiff base compound.
- To characterize the molecular conformation and packing in the solid state.
Main Methods:
- Single-crystal X-ray diffraction was employed to determine the molecular and crystal structure.
- Analysis of bond lengths, bond angles, and dihedral angles provided conformational insights.
- Intermolecular interactions, including hydrogen bonding and C-H⋯O interactions, were identified.
Main Results:
- The Schiff base compound C(14)H(12)N(4)O(3) was synthesized and characterized.
- The molecule exhibits an E conformation around the C=N imine bond (1.268(3) Å).
- A dihedral angle of 3.2(5)° between benzene rings indicates a nearly planar molecular geometry.
- N-H⋯O, N-H⋯N, and C-H⋯O interactions facilitate the formation of layered structures stacked along the c axis.
Conclusions:
- The study provides a detailed structural description of the Schiff base compound.
- The identified hydrogen bonding network explains the observed layered crystal packing.
- This structural information is valuable for the design of new functional materials.
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