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Updated: May 21, 2026

Facile Preparation of 4-Substituted Quinazoline Derivatives
Published on: February 15, 2016
1-(4-Chloro-butano-yl)-3-(2-nitro-phen-yl)thio-urea
Abstract:
The asymmetric unit of the title compound, C(11)H(12)ClN(3)O(3)S, contains two independent mol-ecules with different conformations in which the benzene ring and the thio-urea fragment form dihedral angles of 87.28 (12) and 66.44 (10)°. The O atom of the thio-amide group is involved in bifurcated N-H⋯O intra- and inter-molecular hydrogen bonding; the latter inter-action links the independent mol-ecules into a dimer. In the crystal, N-H⋯S inter-actions link the mol-ecules into chains propagating along the c axis.
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