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3-Amino-N-benzyl-6-(4-fluoro-phen-yl)thieno[2,3-b]pyridine-2-carboxamide
Jin-Ni Zhao1, Sheng-Yong Yang, Li Yang
1State Key Laboratory of Biotherapy and Cancer Center, West China Hospital, West China Medical School, Sichuan University, Chengdu 610041, People's Republic of China.
Abstract:
In the title compound, C(21)H(16)FN(3)OS, the thieno[2,3-b]pyridine system forms dihedral angles of 10.57 (12) and 83.87 (5)° with the fluoro-phenyl ring at the 6-position and the phenyl ring of the benzyl group, respectively. In the crystal, mol-ecules are linked by weak N-H⋯N anf N-H⋯O hydrogen bonds and π-π stacking inter-actions involving fluoro-phenyl rings of adjacent mol-ecules, with a centroid-centroid distance of 3.648 (10) Å. In addition, intra-molecular N-H⋯S and N-H⋯O hydrogen bonds contribute to the stability of the mol-ecular conformation.
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