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Updated: May 21, 2026
11:01
Preparation and In Vivo Use of an Activity-based Probe for N-acylethanolamine Acid Amidase
Published on: November 23, 2016
N-Cyclo-hexyl-2-oxo-2-phenyl-acetamide.
1Laboratory of Asymmetric Catalysis and Synthesis, Department of Chemistry, Zhejiang University, Hangzhou, Zhejiang 310027, People's Republic of China.
Summary
This study details the molecular structure of C(14)H(17)NO(2), revealing specific carbonyl group orientation and a chair conformation for its cyclohexane ring. Molecules form hydrogen-bonded chains in the crystal structure.
Area of Science:
- Organic Chemistry
- Crystallography
- Molecular Structure Analysis
Background:
- Understanding molecular conformation and intermolecular interactions is crucial in chemical research.
- Crystallography provides detailed insights into the three-dimensional arrangement of atoms in solid-state compounds.
Purpose of the Study:
- To elucidate the precise molecular geometry and crystal packing of the compound C(14)H(17)NO(2).
- To characterize the hydrogen bonding network and its influence on the solid-state structure.
Main Methods:
- Single-crystal X-ray diffraction was employed to determine the crystal structure.
- Analysis of torsion angles and bond conformations was performed.
Main Results:
- The compound C(14)H(17)NO(2) exhibits a specific torsion angle of -129.9(3)° between its two carbonyl groups.
- The cyclohexane ring adopts a stable chair conformation.
- Intermolecular N-H⋯O hydrogen bonds link molecules into a one-dimensional chain along the crystallographic a axis.
Conclusions:
- The crystal structure of C(14)H(17)NO(2) is characterized by specific conformational preferences and a defined hydrogen bonding motif.
- The observed chain structure highlights the role of intermolecular forces in dictating crystal architecture.
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The IUPAC and common names of amides are derived from the parent carboxylic acid, by replacing the suffix “oic acid” and “ic acid,” respectively, with “amide.” In the following example, the IUPAC name ethanamide is derived from ethanoic acid, and the common name, acetamide, is obtained from acetic acid.
The IUPAC and common names of amides are derived from the parent carboxylic acid, by replacing the suffix “oic acid” and “ic acid,” respectively, with “amide.” In the following example, the IUPAC name ethanamide is derived from ethanoic acid, and the common name, acetamide, is obtained from acetic acid.
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01:18Aromatic Hydrocarbon Cations: Structural Overview
Cycloheptatriene is a neutral monocyclic unsaturated hydrocarbon that consists of an odd number of carbon atoms and an intervening sp3 carbon in the ring. The three double bonds in the ring correspond to 6 π electrons, which is a Huckel number, and therefore satisfies the criteria of 4n + 2 π electrons. However, the intervening sp3 carbon disrupts the continuous overlap of p orbitals. As a result, cycloheptatriene is not aromatic.
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01:09IUPAC Nomenclature of Ketones
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01:28Structures of Carboxylic Acid Derivatives
Structure of Carboxylic Acid Derivatives
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