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Partial androgen deficiency, depression, and testosterone supplementation in aging men
Mario Amore1, Marco Innamorati, Sara Costi
1Department of Neurosciences, Institute of Psychiatry, University of Parma, Piazza Matteotti 9, 43100 Parma, Italy.
International Journal of Endocrinology
|June 22, 2012
Summary
Low testosterone levels in aging men are linked to depression, but testosterone treatment shows limited effectiveness for mood. However, it may improve quality of life aspects like sexual function and cognition.
Area of Science:
- Endocrinology
- Geriatrics
- Psychiatry
Background:
- Partial androgen deficiency of the aging male (PADAM) is associated with depressive symptoms.
- The relationship between hypogonadism and depression is complex and not fully understood.
- Low testosterone levels are frequently observed in men with depression, and vice versa.
Purpose of the Study:
- To review the current understanding of the link between depressive symptoms and PADAM.
- To evaluate the potential benefits of testosterone (T) treatment on mood in aging men.
Main Methods:
- Systematic literature review.
- Analysis of studies investigating testosterone levels, depressive symptoms, and PADAM.
- Evaluation of clinical trial data on testosterone supplementation for mood disorders.
Main Results:
- A correlation exists between depressive symptoms and PADAM, though causality is uncertain.
- Testosterone supplementation has not demonstrated significant efficacy in treating depression.
- Testosterone therapy shows benefits in improving sexual function, cognitive function, and muscle strength in aging men with PADAM.
Conclusions:
- While testosterone treatment may not be a primary therapy for depression in aging men, it can positively impact other quality-of-life domains.
- Further research is needed to clarify the causal relationship between testosterone deficiency and depression.
- Management of PADAM may involve considering testosterone supplementation for specific symptoms beyond mood.
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