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Aip1p Dynamics Are Altered by the R256H Mutation in Actin
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Withaferin a alters intermediate filament organization, cell shape and behavior

Boris Grin1, Saleemulla Mahammad, Tatjana Wedig

  • 1Department of Cell and Molecular Biology, Feinberg School of Medicine at Northwestern University, Chicago, Illinois, United States of America. r-goldman@northwestern.edu

Plos One
|June 22, 2012
PubMed
Summary

Withaferin A (WFA) reorganizes vimentin intermediate filaments (VIF) and affects other cellular structures, potentially leading to apoptosis or senescence. Caution is advised for its use as an anti-cancer agent due to potential organism-wide effects.

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