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Updated: May 21, 2026
08:02
In Vivo Immunogenicity Screening of Tumor-Derived Extracellular Vesicles by Flow Cytometry of Splenic T Cells
Published on: September 23, 2021
Trial watch: Chemotherapy with immunogenic cell death inducers
Erika Vacchelli1, Lorenzo Galluzzi, Wolf Hervé Fridman
1U848; Villejuif, France; INSERM; Université Paris-Sud/Paris XI; Paris, France.
Oncoimmunology
|June 22, 2012
Summary
Certain cancer cell deaths can trigger immune responses against tumors. This review examines clinical trials of chemotherapy drugs like cyclophosphamide and doxorubicin for their potential to induce immunogenic cell death.
Area of Science:
- Immunology
- Oncology
- Pharmacology
Background:
- The traditional view of apoptosis as immunologically silent is being challenged.
- Cancer cells can undergo apoptosis, initiating an antitumor immune response.
- This immunogenic cell death is crucial for long-term cancer immunity.
Purpose of the Study:
- To review recent clinical trials evaluating off-label uses of specific anticancer agents.
- To discuss the potential of these agents to induce immunogenic cell death.
- To explore the role of these agents in stimulating antitumor immune responses.
Main Methods:
- Review of clinical trials initiated after January 2008.
- Focus on off-label use of cyclophosphamide, doxorubicin, oxaliplatin, and mitoxantrone.
- Analysis of trials assessing the induction of immunogenic cell death.
Main Results:
- Several anticancer agents, including cyclophosphamide, doxorubicin, oxaliplatin, and mitoxantrone, can stimulate immunogenic cell death.
- These agents are approved for various malignancies and show promise in ongoing trials.
- Evidence suggests these drugs can elicit protective antitumor immune responses.
Conclusions:
- The concept of immunogenic cell death is gaining traction in cancer therapy.
- Off-label use of established chemotherapy drugs may offer new avenues for cancer immunotherapy.
- Further research into these agents could enhance cancer treatment strategies.
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