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Related Concept Videos

Tumor Immunotherapy01:27

Tumor Immunotherapy

Immunotherapy is a treatment that boosts or manipulates the immune system to fight diseases, including cancer. For instance, by stimulating an immune response through vaccinations against viruses that cause cancers, like hepatitis B virus and human papillomavirus, these diseases can be prevented. Nonetheless, some cancer cells can avoid the immune system due to their rapid mutation and division. The immune response to many cancers involves three phases: elimination, equilibrium, and escape.
Cancer Therapies02:49

Cancer Therapies

Cancer therapies are various modes of treatment, such as surgery, radiation therapy, and chemotherapy that are administered to cancer patients.
However, cancer treatments can pose several challenges, as therapies used to kill cancer cells are generally also toxic to normal cells. Moreover, cancer cells mutate rapidly and can develop resistance to chemical agents or radiation therapy. Besides, all types of cancer cells may not respond to the same therapy. Some cancer cells respond to one...
Targeted Cancer Therapies02:57

Targeted Cancer Therapies

The targeted cancer therapies, also known as “molecular targeted therapies,” take advantage of the molecular and genetic differences between the cancer cells and the normal cells. It needs a thorough understanding of the cancer cells to develop drugs that can target specific molecular aspects that drive the growth, progression, and spread of cancer cells without affecting the growth and survival of other normal cells in the body.
There are several types of targeted therapies against specific...
Cancer Vaccines01:30

Cancer Vaccines

Cancer treatment vaccines are a rapidly evolving field that offers a promising approach to immunotherapy. Unlike traditional vaccines that prevent diseases, cancer treatment vaccines are designed to treat existing cancers by stimulating the immune system to recognize and attack cancer cells.
Cancer vaccines come in two categories: preventive (prophylactic) and treatment (active). Preventive vaccines, such as the Human Papillomavirus (HPV) vaccine, protect against viruses that cause certain...
Combination Therapies and Personalized Medicine02:50

Combination Therapies and Personalized Medicine

Combining two or more treatment methods increases the life span of cancer patients while reducing damage to vital organs or tissue from the overuse of a single treatment. Combination therapy also targets different cancer-inducing pathways, thus reducing the chances of developing resistance to treatment.
The combination of the drug acetazolamide and sulforaphane is a good example of combination therapy to treat cancer. The cells in the interior of a large tumor often die due to the hypoxic and...
The Tumor Microenvironment02:17

The Tumor Microenvironment

Every normal cell or tissue is embedded in a complex local environment called stroma, consisting of different cell types, a basal membrane, and blood vessels. As normal cells mutate and develop into cancer cells, their local environment also changes to allow cancer progression. The tumor microenvironment (TME) consists of a complex cellular matrix of stromal cells and the developing tumor. The cross-talk between cancer cells and surrounding stromal cells is critical to disrupt normal tissue...

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Related Experiment Video

Updated: May 21, 2026

Intramucosal Inoculation of Squamous Cell Carcinoma Cells in Mice for Tumor Immune Profiling and Treatment Response Assessment
07:29

Intramucosal Inoculation of Squamous Cell Carcinoma Cells in Mice for Tumor Immune Profiling and Treatment Response Assessment

Published on: April 22, 2019

Immunotherapy: Is it different for sarcomas?

Anne-Marie Cleton-Jansen1, Emilie P Buddingh, Arjan C Lankester

  • 1Department of Pathology; Leiden University Medical Center; Leiden, The Netherlands.

Oncoimmunology
|June 22, 2012
PubMed
Summary

Macrophages play dual roles in cancer. In osteosarcoma, these immune cells appear to inhibit metastasis, a finding that warrants further investigation into the underlying mechanisms.

Area of Science:

  • Immunology
  • Oncology
  • Cell Biology

Background:

  • Macrophages exhibit dual roles in cancer, with both tumor-suppressive and tumor-promoting functions.
  • While typically promoting tumor growth in epithelial cancers, macrophages may have a different role in osteosarcoma.
  • Recent findings suggest macrophages inhibit osteosarcoma metastasis.

Purpose of the Study:

  • To explore the potential mechanism by which macrophages inhibit osteosarcoma metastasis.
  • To elucidate the specific interactions between macrophages and osteosarcoma cells that influence metastatic potential.

Main Methods:

  • This study is a discussion of recent findings and proposed mechanisms.
  • It involves a review of existing literature and experimental data on macrophage-osteosarcoma interactions.

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Isolation and Characterization of Tumor-initiating Cells from Sarcoma Patient-derived Xenografts
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Isolation and Characterization of Tumor-initiating Cells from Sarcoma Patient-derived Xenografts

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Last Updated: May 21, 2026

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Published on: April 22, 2019

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  • Hypotheses regarding cellular and molecular pathways are presented.

    • Main Results:

    • Macrophages may exert tumor-suppressive effects in the context of osteosarcoma.
    • The observed inhibition of metastasis by macrophages in osteosarcoma is a novel finding.
    • Potential mechanisms involve modulation of the tumor microenvironment and direct cell-cell interactions.

    Conclusions:

    • Macrophages might represent a novel therapeutic target for inhibiting osteosarcoma metastasis.
    • Further research is needed to fully understand and harness the anti-metastatic potential of macrophages in osteosarcoma.
    • The distinct role of macrophages in osteosarcoma contrasts with their typical pro-tumorigenic function in other cancers.