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Interstitial chemotherapy of experimental gliomas
W J Zeller1, S Bauer, T Remmele
1Institute of Toxicology and Chemotherapy, German Cancer Research Center, Heidelberg.
Cancer Treatment Reviews
|September 1, 1990
Abstract:
Two new approaches of interstitial (intratumoral) chemotherapy of gliomas are presented. Using s.c.-transplanted rat gliomas (G616) the therapeutic activity of biologically degradable polylactide rods as carriers for methotrexate was investigated. Carrier-mediated intratumoral chemotherapy was superior both to a systemic treatment and an intratumoral treatment with the free drug. The activity of the alkyllysophospholipids Et-18-OCH3 and BM 41.440 and of the alkylphosphocholine He-PC was investigated in a human glioma xenograft (T 406). All three compounds were highly active following intratumoral administration.