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Related Experiment Videos

Propranolol in acute migraine: a controlled study.

G N Fuller1, R J Guiloff

  • 1Department of Neurology, Charing Cross and Westminster Medical School, Westminster Hospital, London, UK.

Cephalalgia : an International Journal of Headache
|October 1, 1990
PubMed
Summary
This summary is machine-generated.

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Propranolol did not show significant benefits for acute migraine attacks in this study. This double-blind, placebo-controlled trial found no difference in symptom severity or duration compared to placebo.

Area of Science:

  • Neurology
  • Pharmacology

Background:

  • Propranolol is widely used for migraine prevention.
  • Previous uncontrolled studies suggested potential efficacy in treating acute migraine attacks.

Purpose of the Study:

  • To evaluate the efficacy of propranolol in the acute treatment of migraine through a double-blind, placebo-controlled study.

Main Methods:

  • 27 patients with common or classical migraine were enrolled.
  • A double-blind, placebo-controlled design was used, comparing propranolol 40 mg to placebo during acute attacks.
  • Data were analyzed by headache pair and by patient.

Main Results:

  • 14 patients completed the study, contributing 23 headache pairs.
  • No statistically significant difference was observed between propranolol and placebo in terms of headache severity, duration, or subjective efficacy.

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Conclusions:

  • Propranolol (40 mg) is not effective for the acute treatment of common or classical migraine attacks.
  • Further research may be needed to explore other dosages or formulations for acute migraine management.