Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Experiment Videos

Neuroendocrine dysfunction in cluster headache.

M Leone1, G Patruno, A Vescovi

  • 1Istituto Neurologico C. Besta, Milano, Italy.

Cephalalgia : an International Journal of Headache
|October 1, 1990
PubMed
Summary
This summary is machine-generated.

Related Concept Videos

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

Induced pluripotent stem cell production (CSSi019-A)(14432) from an asymptomatic subject carrying a expansion of C9orf72 gene.

Stem cell research·2024
Same author

Somatosensory tinnitus and temporomandibular disorders: A common association.

Journal of oral rehabilitation·2023
Same author

Factors associated with hospital admission and adverse outcome for COVID-19: Role of social factors and medical care.

Infectious diseases now·2022
Same author

Predictive role of gnathological techniques for the treatment of persistent idiopathic facial pain (PIFP).

Neurological sciences : official journal of the Italian Neurological Society and of the Italian Society of Clinical Neurophysiology·2020
Same author

Patients with MS treated with immunosuppressive agents: Across the COVID-19 spectrum.

Revue neurologique·2020
Same author

Lifestyle among urology trainees and young urologist in the context of burn-out syndrome.

Actas urologicas espanolas·2019
Same journal

Cerebrovascular risk with calcitonin gene-related peptide monoclonal antibodies versus onabotulinumtoxinA in patients with migraine: A real-world pharmacoepidemiologic study in the National Institutes of Health All of Us Research Program.

Cephalalgia : an international journal of headache·2026
Same journal

Burning mouth syndrome and oral dysaesthetic/perceptual symptoms: Toward clinically actionable boundaries.

Cephalalgia : an international journal of headache·2026
Same journal

Effectiveness and clinical predictors of rimegepant for acute vertigo in vestibular migraine: A real-world cohort study.

Cephalalgia : an international journal of headache·2026
Same journal

Efficacy of digital therapeutic sinCephalea for personalised nutrition versus control for migraine prevention: A 12-week open-label randomised clinical trial.

Cephalalgia : an international journal of headache·2026
Same journal

SafeTy and effectiveness of Atogepant accoRding to the IHS outcome categories: A multicentric, prospective observational study in real life (the 24-week STAR study).

Cephalalgia : an international journal of headache·2026
Same journal

Placebo or active comparator in chronic migraine trials: Balancing evidence and practicality.

Cephalalgia : an international journal of headache·2026
See all related articles

Cluster headache patients during active periods show reduced hypothalamic-pituitary axis response, suggesting central nervous system dysfunction. This finding supports a hypothalamic role in cluster headache pathogenesis.

Area of Science:

  • Neurology
  • Neuroendocrinology

Background:

  • Cluster headache is thought to involve primary central nervous system dysfunction.
  • Hypothalamic involvement is a key hypothesis in cluster headache pathogenesis.

Purpose of the Study:

  • To investigate hypothalamic involvement in cluster headache.
  • To evaluate the hypothalamic-pituitary axis responsiveness using the thyrotrophin-releasing hormone (TRH) test.

Main Methods:

  • Administered 200 micrograms of TRH intravenously to three groups: nine healthy controls, 32 cluster headache patients during an active period, and 16 patients in remission.
  • Measured the delta maximum thyrotropin (TSH) levels in all participants.

Main Results:

  • Significantly lower delta maximum TSH levels were observed in cluster headache patients during the active period compared to healthy controls and patients in remission (p < 0.05).

Related Experiment Videos

  • No significant difference in delta maximum TSH levels was found between healthy controls and cluster headache patients in remission.

    • Conclusions:

    • The findings suggest impaired hypothalamic-pituitary axis responsiveness during active cluster headache periods.
    • A hypothalamic monoaminergic dysfunction is hypothesized as a contributing factor to cluster headache pathophysiology.