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Xeroderma pigmentosum: clonal chromosomal rearrangements in a pre-cancerous skin lesion
L Chessa1, F Nuzzo, M Stefanini
1Cattedra di Genetica Medica, Università La Sapienza, Roma, Italy.
Disease Markers
|May 1, 1990
Abstract:
In cells from a papulonodular formation of a patient with the clinical and cellular phenotype of the variant form of xeroderma pigmentosum (XP-V), clonal rearrangements involving different chromosomes were observed. This finding confirms the literature data suggesting that multiple non-specific chromosome anomalies are typical of pre-malignant and malignant skin lesions.