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Related Concept Videos

Antiasthma Drugs: Inhaled Corticosteroids and Glucocorticoids01:25

Antiasthma Drugs: Inhaled Corticosteroids and Glucocorticoids

Inhaled corticosteroids (ICS) are anti-inflammatory drugs used primarily in treating persistent asthma and providing long-term maintenance. They target the bronchial mucosa, the lining of the airways, to control inflammation, a critical factor in asthma progression and exacerbation.
ICS work through a multifaceted mechanism of action. They suppress the inflammatory response caused by the proliferation of TH cells. They also reduce the transcription of the IL-2 gene, which is involved in the...
Asthma: Pathogenesis and Management01:20

Asthma: Pathogenesis and Management

Asthma is a chronic pulmonary condition involving inflammation of the airways, hyper-reactivity, and reversible obstruction of the airways. This condition can significantly impact a person's quality of life, making breathing difficult and leading to distressing symptoms.
Asthma is classified as allergic and non-allergic. Allergens such as dust mites, pollen, and pet dander trigger allergic asthma, while factors like cold air, intense emotions, or exercise can induce non-allergic asthma.
Antiasthma Drugs: Mast Cell Stabilizers and Anti-IgE Drugs01:25

Antiasthma Drugs: Mast Cell Stabilizers and Anti-IgE Drugs

Asthma is a chronic respiratory condition for which new therapeutic avenues, including anti-inflammatory drugs like mast cell stabilizers and anti-IgE treatments, continue to be developed.
Mast cell stabilizers, such as cromolyn (also known as sodium cromoglycate) and nedocromil (Tilade), are effective drugs in asthma management. These stabilizers hinder histamine release by skillfully obstructing the activation of mast cells and other cellular entities. Notably, they navigate this task without...
Antiasthma Drugs: Muscarinic Receptor Antagonists01:20

Antiasthma Drugs: Muscarinic Receptor Antagonists

Muscarinic receptor antagonists, also known as antimuscarinic agents, are a class of bronchodilators used to treat asthma, although they are more commonly used to treat COPD. They work by inhibiting the action of acetylcholine (ACh), a neurotransmitter, on muscarinic receptors found in the airways.
Antimuscarinic agents compete with ACh for the same binding site on the muscarinic receptors. By binding to these receptors, they inhibit the downstream effects of ACh and block the parasympathetic...
Asthma I: Introduction01:28

Asthma I: Introduction

Asthma is a chronic inflammatory disorder of the airways characterized by variable airflow obstruction and heightened bronchial responsiveness to a wide range of triggers. The underlying inflammation leads to airway swelling, mucus hypersecretion, and smooth muscle constriction, all of which narrow the airway lumen and impede airflow. Clinically, asthma presents with recurrent episodes of wheezing, shortness of breath, chest tightness, and coughing, symptoms that typically vary in intensity and...
Asthma-II: Pathophysiology and Classification01:26

Asthma-II: Pathophysiology and Classification

Asthma is a prevalent chronic respiratory condition marked by inflammation and hyperresponsiveness of the airways. Its pathophysiology involves complex interactions among inflammatory pathways, immune responses, and neural mechanisms.
Additionally, environmental and genetic factors play crucial roles in determining an individual's susceptibility to asthma and the severity of their condition.
Critical processes in asthma pathophysiology include:

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Related Experiment Video

Updated: May 21, 2026

Murine Model of Allergen Induced Asthma
08:05

Murine Model of Allergen Induced Asthma

Published on: May 14, 2012

Corticosteroids and antigen avoidance decrease airway smooth muscle mass in an equine asthma model.

Mathilde Leclere1, Anouk Lavoie-Lamoureux, Philippe Joubert

  • 1Department of Veterinary Clinical Sciences, Université de Montréal, Saint-Hyacinthe, Quebec, Canada.

American Journal of Respiratory Cell and Molecular Biology
|June 23, 2012
PubMed
Summary
This summary is machine-generated.

Inhaled corticosteroids may speed up airway smooth muscle remodeling reversal in horses with asthma-like heaves. Antigen avoidance better controlled inflammation, but fluticasone propionate accelerated smooth muscle mass reduction.

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Murine Model of Allergen Induced Asthma
08:05

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Published on: May 14, 2012

Development of an in vitro model system for studying the interaction of Equus caballus IgE with its high-affinity receptor FcεRI
07:31

Development of an in vitro model system for studying the interaction of Equus caballus IgE with its high-affinity receptor FcεRI

Published on: November 1, 2014

Area of Science:

  • Veterinary Medicine
  • Pulmonary Medicine
  • Immunology

Background:

  • Airway smooth muscle remodeling is an early feature of asthma.
  • The impact of long-term antigen avoidance and inhaled corticosteroids on established airway remodeling is not well understood.

Purpose of the Study:

  • To evaluate the effects of inhaled corticosteroids and antigen avoidance on airway remodeling in horses with heaves, a naturally occurring asthma-like condition.
  • To compare the efficacy of fluticasone propionate and antigen avoidance in reversing airway smooth muscle remodeling.

Main Methods:

  • Adult horses with heaves were treated with fluticasone propionate (with or without antigen avoidance) or antigen avoidance alone.
  • Lung function, bronchoalveolar lavage, and peripheral lung biopsies were assessed before and after 6 and 12 months of treatment.

Main Results:

  • Lung function improved faster with inhaled corticosteroids, while inflammation was better controlled with antigen avoidance.
  • Smooth muscle mass decreased significantly by 6 months in the fluticasone group and by approximately 30% in both groups over 12 months.
  • Subepithelial collagen area decreased in both treatment groups by 12 months.

Conclusions:

  • Inhaled corticosteroids may accelerate the reversal of airway smooth muscle remodeling in heaves.
  • While antigen avoidance improves inflammation control, fluticasone propionate demonstrates a faster reduction in smooth muscle mass.