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Related Experiment Video

Updated: May 21, 2026

A Novel Tenorrhaphy Suture Technique with Tissue Engineered Collagen Graft to Repair Large Tendon Defects
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Tendon coverage using an artificial skin substitute.

Jaimie T Shores1, Matthew Hiersche, Allen Gabriel

  • 1Johns Hopkins University School of Medicine, Department of Plastic and Reconstructive Surgery, Baltimore, MD, USA.

Journal of Plastic, Reconstructive & Aesthetic Surgery : JPRAS
|June 23, 2012
PubMed
Summary
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Integra Bilayer Matrix Wound Dressing effectively reconstructs soft tissue defects over exposed tendons, showing high graft take and excellent tendon function. This offers a viable alternative for upper and lower extremity reconstructions.

Area of Science:

  • Regenerative Medicine
  • Wound Healing
  • Orthopedic Surgery

Background:

  • Exposed tendons without paratenon present significant reconstructive challenges, leading to adhesions, limited motion, and poor outcomes.
  • Integra Bilayer Matrix Wound Dressing is a skin substitute used in reconstructive surgery, but its efficacy for tendon coverage is not well-documented.
  • This study investigates Integra's use in soft tissue reconstruction over exposed tendons in upper and lower extremities.

Purpose of the Study:

  • To evaluate the effectiveness of Integra Bilayer Matrix Wound Dressing for soft tissue reconstruction over exposed tendons.
  • To assess post-operative outcomes, including graft take and range of motion, following Integra application.
  • To compare the results with existing literature on exposed tendon treatment.

Main Methods:

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06:36

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Published on: December 10, 2021

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  • A prospective study of 42 patients with exposed tendons due to trauma, cancer excision, or chronic wounds.
  • Integra Bilayer Matrix Wound Dressing was used for reconstruction, followed by split-thickness skin grafting.
  • Data collected included patient demographics, wound characteristics, operative details, graft take, and active post-operative range of motion.

Main Results:

  • All patients achieved successful wound healing with an average split-thickness skin graft take of 92.5%.
  • Patients achieved an average active post-operative range of motion of 91.2% in the 32 patients with complete follow-up.
  • No significant donor site morbidity was reported.

Conclusions:

  • Integra provides a convenient and efficient surgical option for soft tissue reconstruction over exposed tendons.
  • The procedure demonstrates good cosmetic results and restores tendon function effectively.
  • Integra serves as a valuable alternative for immediate tendon coverage in both upper and lower extremity defects.