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Human Virome

Human Virome

The human body harbors a vast and diverse viral community known as the human virome. The virome includes bacteriophages that infect bacteria, and eukaryotic viruses that infect human cells. Transient dietary and environmental viruses also contribute to this dynamic ecosystem. Estimates suggest the human body may contain on the order of 10¹³ viral particles, though abundance varies widely by body site and detection method.Comprehensive characterization of the virome has become possible only with...

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Assays for the Specific Growth Rate and Cell-binding Ability of Rotavirus

Assays for the Specific Growth Rate and Cell-binding Ability of Rotavirus

Published on: January 28, 2019

Towards a human rotavirus disease model.

Marie Hagbom¹, Sumit Sharma, Ove Lundgren

¹Division of Molecular Virology, University of Linköping, 581 85, Linköping, Sweden.

Current Opinion in Virology

|June 23, 2012

Summary

This summary is machine-generated.

Human rotavirus (RV) causes severe gastroenteritis, but its exact mechanisms remain unclear. This review synthesizes current knowledge on RV disease, symptoms, and treatments, proposing a simplified disease model.

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Published on: December 10, 2013

Area of Science:

Virology
Gastroenterology
Pathophysiology

Background:

Human rotavirus (RV) is a significant cause of diarrheal disease globally.
Despite effective vaccines, the precise mechanisms underlying RV-induced illness are not fully understood.

Purpose of the Study:

To review the clinical symptoms, pathology, histology, and treatment of human rotavirus infections.
To compile existing data into a simplified model of RV disease pathogenesis.

Main Methods:

Literature review of clinical symptoms, pathology, histology, and treatment practices for human rotavirus.
Synthesis of data to develop a simplified disease model.

Main Results:

Oral rehydration effectiveness suggests functional sodium-glucose cotransporters in enterocytes.
Delayed gastric emptying and response to loperamide indicate enteric nervous system involvement.
Serotonin (5-HT) antagonists and zinc/enkephalinase inhibitors show potential in managing RV symptoms.

Conclusions:

Understanding RV pathogenesis involves electrolyte transport, gastric emptying, and the enteric nervous system.
Further research is needed to fully elucidate RV's impact on the gastrointestinal tract.
A simplified disease model can aid in understanding and managing rotavirus infections.