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Related Concept Videos

Preclinical Development: Overview01:28

Preclinical Development: Overview

Preclinical development consists of a series of tests that ensure the safety and efficacy of a new therapeutic compound before it is tested in humans. There are four main phases to this process. First, safety pharmacology tests are conducted to ensure the drug does not produce any acutely harmful effects. These tests examine parameters such as bronchoconstriction, cardiac dysrhythmias, blood pressure changes, and ataxia. Next, preliminary toxicological testing is performed to determine the...
Clinical Trials: Overview01:11

Clinical Trials: Overview

Clinical development focuses on how the drug will interact with the human body and encompasses four key phases of clinical trials, each serving a specific purpose in assessing the safety and effectiveness of new drugs. These phases overlap and build upon one another. Phase I involves a small group of healthy volunteers (typically 20-80 individuals) or, in cases where significant toxicity is expected, patients with the targeted disease, such as cancer or AIDS. The volunteers are tested for...
Clinical Trials01:16

Clinical Trials

Clinical trials are prospective experimental studies conducted on humans to determine the safety and efficacy of treatments, drugs, diet methods, and medical devices. Using statistics in clinical trials enables researchers to derive reasonable and accurate conclusions from the collected data, allowing them to make wise decisions in uncertain situations. In medical research, statistical methods are crucial for preventing errors and bias.
There are four phases in a clinical trial. A phase one...
Interdisciplinary Care: The Health Care Team-II01:18

Interdisciplinary Care: The Health Care Team-II

An interdisciplinary team includes many healthcare professionals working together and utilizing their skills, knowledge, and expertise to provide holistic and quality patient care. Here are a few more healthcare professionals.
Physical Therapist
A physical therapist (PT) aims to restore function or prevent additional impairment in a patient following an injury or disease. Massage, heat, cold, water, sonar waves, exercises, and electrical stimulation are some treatments used by PTs to treat...
Interdisciplinary Care: The Health Care Team-I01:21

Interdisciplinary Care: The Health Care Team-I

An interdisciplinary team includes many healthcare professionals working together and utilizing their skills, knowledge, and expertise to provide holistic and quality patient care.
Physicians
The physician's primary responsibility is to diagnose illness and direct the medical or surgical treatment of the condition. The authority to admit patients to a healthcare agency or institution and practice care within that setting is granted to physicians by the healthcare agency or institution itself.
Translational Regulation01:29

Translational Regulation

Translational regulation in prokaryotes ensures efficient protein synthesis by controlling ribosome access to mRNA. This regulation is mediated by secondary RNA structures, including translational riboswitches, RNA thermometers, and small RNAs (sRNAs), which respond to intracellular and environmental signals to modulate gene expression.Translational RiboswitchesRiboswitches in the leader region of mRNAs can regulate translation by altering the accessibility of the Shine-Dalgarno (SD) sequence,...

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Clinical and translational research studios: a multidisciplinary internal support program.

Daniel W Byrne1, Italo Biaggioni, Gordon R Bernard

  • 1Department of Biostatistics, Vanderbilt University School of Medicine, Nashville, TN 37232-2158, USA. daniel.byrne@vanderbilt.edu

Academic Medicine : Journal of the Association of American Medical Colleges
|June 23, 2012
PubMed
Summary
This summary is machine-generated.

The Studio Program offers medical researchers free, expert feedback to enhance scientific quality and impact. This program facilitates collaborative discussions, significantly improving research projects across various disciplines.

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Area of Science:

  • Biomedical Research
  • Translational Science
  • Academic Medicine

Background:

  • The Vanderbilt Institute for Clinical and Translational Research established the Studio Program in 2007.
  • The program aims to improve the quality and impact of biomedical research through expert consultation.
  • Vanderbilt's Clinical and Translational Science Award supports this initiative.

Purpose of the Study:

  • To describe the design of the Studio Program.
  • To evaluate the program's effectiveness during its first four years of operation.

Main Methods:

  • Investigators apply online, and a manager assembles a panel of 3-6 experts.
  • Seven Studio formats are available, tailored to specific research needs (e.g., study design, grant review).
  • Sessions are 90-minute moderated roundtable discussions.

Main Results:

  • 157 Studio sessions were conducted in the first four years.
  • 99% of investigators reported improved science quality.
  • 98% of experts found the sessions a valuable use of their time.

Conclusions:

  • The Studio Program effectively enhances the quality and impact of medical research.
  • The program demonstrates high satisfaction rates among both researchers and expert consultants.
  • The collaborative, multidisciplinary feedback model is a valuable resource for investigators.